The Correlation Between Ureterovesical Junction Injury Of New Zealand Male Rabbits And Vesicoureteral Reflux

Objective To observe the situation of occurrence of vesicoureteral reflux after destroying the New Zealand male rabbits of different lengths of ureterovesical junction, and preliminarily explore the change of bladder capacity, pressure within the ipsilateral renal pelvis,pathological of kidney(renal pelvis, renal parenchyma) in the case of the destruction of different ureterovesical junction’s lengths, so that exploring the correlation and significance between ureterovesical junction injury of New Zealand male rabbits and vesicoureteral reflux.Methods 40 New Zealand rabbits were randomly divided into control group(n=8), sham operation group(n=8),surgery group A(n=8),surgery group B(n=8),surgery group C(n=8),the control group was only anesthetized,the sham group was opened the top wall of the bladder about 1cm and sutured,surgery group A, surgical group B and group C were destroyed the ength of ureterovesical junctionl of 1/3, 2/3,3/3 in turn, again to experimental observation after 8 weeks,observed whether the occurrence and extent of VUR after contrast agent injected into intravesical, to measure bladder capacity and the pressure in the renal pelvis and pathological changes in kidney tissue.Results In control group, sham operation group, surgery group A,surgery group B, had no VUR, surgery group C had different degrees of reflux, which level I 1case, II Level 2 cases, III 5 cases, and in this group there were significantly reduced bladder capacity and increased the pressure in the renal pelvis,renal pelvis dilation with thinning of the transitional cell epithelial layer was observed,focal thinning of the tubular epithelium and interstitial widening were observed in part of the kidney(4/8 cases).Conclusion Ureterovesical junction and vesicoureteral reflux are directly correlated; Destruction of Ureterovesical junction within two-thirds of the length does not cause vesicoureteral reflux; Pelvis within the pressure increases when vesicoureteral reflux happens, the long-lasting increase may cause damage to kidney function;The top wall of the bladder was not correlated with VUR.