Screening And Analysis Of Clinical Risk Factors For Systemic Lupus Erythematosus(SLE) In Patients With Invasive Fungal Disease (IFD)

Objective:Study of systemic lupus erythematosus (SLE) patients complicated with in vasive fungal disease (IFD) clinical risk factors.Methods:We collected from January,2009 to December,2013 in the Second Affili ated Hospital of Kunming Medical University dermatology/rheumatology ward fo r the diagnosis of SLE in patients with IFD. A total of 27 cases during the same peri od. At the same time, we collected IFD and other infections did not occur in SLE pat ients as the control group. With reference to a large number of related literature at do mestic and abroad. According to the characteristics and contents of the the study furth er improvement. The main contents include:investigation of hospital number,Name g ender,Age,Nation,course of disease,the underlying disease,complications,suspected i nfection symptoms,the use of glucocorticoid dosage and period of treatment,the use o f immunosuppressants and treatment,the use of broad-spectrum antibiotics,invasive op eration. Lymphocyte count,CRP,complement,finally using the single factor analysis we re screened.Then using the multi factor Logistic regression analysis showed that indep endent risk factors of SLE combined with IFD.Results:1.The final SLE combined with clinical diagnosis of IFD 27 cases.The contro 1 group of 27 cases.The two groups were 36.74±17.01.39.59±12.41 years. The cours e was 68.26±86.61.84.07±61.11 months. Including age,sex,and the course of diseas e, nation and so on.No statistical difference between the two groups.2.The results of single factor analysis found that 13 factors:SLE activity group (SLED AI score= 8),bacterial infection,suspected infection symptoms (fever, cough, expector ation, pulmonary rales,oral pseudomembrane),lymphocyte count was lower than tha t of the 0.8*1012/L,albumin<30g/L,ESR> 30mm/h,complement C3<0.7mg/L,ds-DN A positive,>10 days of hospitalization days,the dosage of glucocorticoid>45mg/d,glu cocorticoid>10 days of continuous use,immunosuppressant>7 days of continuous us e,the antibiotic>5 days of continuous use.Multi factor analysis showed that only 2 ind ependent risk factors:suspected infection symptoms (fever, cough, expectoration, pul monary rales,oral false membrane,>5 days of continuous use of antibiotics.Conclusion:Analysis of the SLE and IFD risk factors. We found that most risk factor s are related to each other.When the complement,lymphocytes decreased and ESR,D s-DNA positive SLE patients in active stage. At this time will increase with time and d ose of glucocorticoid, immunosuppressants. May be caused by a series of factors le d to the SLE patients with IFD. And the use of antibiotics and (or) fever, pulmonary ra les,oral pseudomembrane suspected infection symptoms is a risk factor for SLE in pat ients with IFD.