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Study Of Chemical Constituents And Hepatoprotective Activity Of Ligusticum Chuanxiong Hort

Posted on:2016-12-04Degree:MasterType:Thesis
Country:ChinaCandidate:G QuFull Text:PDF
GTID:2284330470968516Subject:Medicinal chemistry
Abstract/Summary:PDF Full Text Request
Recorded as Ligusticum Chuanxiong Hort belongs to the Chuanxiong Umbelliferae plant category. Because of regional variations in different names. For example:Kawa, Fu Xiong, Ogawa. But as recorded in Pharmacopoeia name for Ligusticum chuanxiong Hort. Ligusticum Chuanxiong Hort rhizome is irregular in shape, similar to a massive fist shaped and nodules. The length of straight Ligusticum Chuanxiong Hort was about 17cm to 7cm.The appearance of the color of brown, yellow or brown two. There are a large number of parallel convex nodules, texture and surface uneven; the tip of a garden like Ligusticum Chuanxiong Hort, the neck is hollow, the bottom side and round section has many very small root marks, are tuberculiform rugulate. The material is too hard to break. The cross section is a yellow white, yellow and the present. The formation of corrugated annular layer presents lines. Ligusticum Chuanxiong Hort itself with brown oil spots. The smell of sweet and strong, with a hint of sweetness, taste bitter, pungent, micro ma.Now the pharmacological research with the blood circulation , on the ce ntral nervous system, cardiovascular system, smooth muscle, diuretic effect.In order to determine the effective drug ingredients in Rhizoma Chuanxion g, in order to give relevant conditions to determine the effect of Rhizoma Chu anxiong and reference according to the. In this experiment the dried rhizome o f Ligusticum Chuanxiong by methanol heating reflux extraction, extract used in the process of extraction followed by petroleum ether, ethyl acetate and n-but anol. After the separation of various ingredients, has used other techniques, suc h as:gel column chromatography, reversed-phase column chromatography and s ilica gel column chromatography. After the final purification of 7 compounds were obtained respectively:(1) Palmitic acid; (2)β-sitosterol; (3) Daucosterol; (4) a-Linolenic acid; (5) Paraben; (6) Quercetin: (7)Protocatechuate。...
Keywords/Search Tags:Ligusticum chuanxiong Hort, Chemical constitution, Pharmacological action, HepG2 cells, MTT, Hepatoprotective activity
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