The Clinical Effect Of Wenyang Huatan Treatment Of Hashimoto Thyroiditis And Its Effect On IL-6 Levels

Objection:To observe the clinical Wenyang Huatan Chinese herbal medicine joint euthyrox intervention for patients with Pi Shen Yang Xu Xing Hashimoto’s thyroiditis(HT)(hypothyroidism stage),try from the angle of Th2 cytokines interleukin-6(Interleukin-6) expression level to explore the mechanism of traditional Chinese medicine on Hashimoto’s thyroiditis,to provide a theoretical basis for traditional medical treatment mechanism of Hashimoto’s thyroiditis.Methods:To select the clinical Pi Shen Yang Xu Xing Hashimoto’s thyroiditis(hypothyroidism stage) 40 cases for the study, patients were randomly divided into two groups,the intervention group and the control group,each group with 20 cases,people in the control group with oral euthyrox conventional treatment,people in the intervention group with Wenyang Huatan Chinese herbal medicine(granules) treatment on the basis of the oral euthyrox additional services,1 month for a period of treatment,for two consecutive quarters course of treatment.Observe patients with clinical syndromes score before and after the treatment,the changes of thyroid thickness level showned by thyroid ultrasound,detect the changes of thyroid hormone,thyroglobulin antibodies,thyroid peroxidase antibody levels by radioimmunoassay,and the changes of IL-6 levels by ELISA.Results:(1)Before the treatment,IL-6,A-TG,A-TPO in the Pi Shen Yang Xu Xing Hashimoto’s thyroiditis(hypothyroidism stage) positive expression rate(%)was 100% in the intervention group and the control group,the difference was not statistically significant(P> 0.05),described the course of distribution of the two groups have no significant difference and can be compared.(2)The intervention group patients symptom score was 17.75±1.37 before the treatment,after treatment score was 6.60±1.54.Control group patients before the treatment clinical symptoms score was 17.70±1.78,after the treatment score was 9.05±1.85.In the two groups before and after the treatment,the difference was statistically significant(P<0.05),described that both Wenyang Huatan Chinese herbal medicine joint euthyrox intervention,simple euthyrox treatment can improve Pi Shen Yang Xu Xing Hashimoto’s thyroiditis(hypothyroidism stage)clinical syndrome.Wenyang Huatan Chinese herbal medicine joint euthyrox intervention is significantly better than simple euthyrox treatment in improving clinical symptom score.(3)The A-TG,A-TPO expression levels in the two groups,compared to the intervention group difference was statistically significant(P<0.05) before and after the treatment,between the treatment group, the difference was statistically significant(P<0.05)after the treatment,described that Wenyang Huatan Chinese herbal medicine joint euthyrox intervention can significantly reduce the levels of A-TG,A-TPO in patients with Pi Shen Yang Xu Xing Hashimoto’s thyroiditis(hypothyroidism stage).(4)Before the treatment,patients in the intervention group IL-6 level was 24.99±6.09,13.13±3.79 after treatment.Before the treatment,the patients in the control group IL-6 level was 23.52±6.89,22.80±6.56 after treatment.Before and after treatment,compared to the intervention group difference was statistically significant(P<0.05),after the treatment between the two group,the difference was statistically significant(P<0.05),described that Wenyang Huatan Chinese herbal medicine joint euthyrox intervention can significantly reduce the levels of IL-6 in patients with Pi Shen Yang Xu Xing Hashimoto’s thyroiditis(hypothyroidism stage).(5)Clinical drug safety, adverse events occurred.Conclusions:Wenyang Huatan method of treating Pi Shen Yang Xu Xing Hashimoto’s thyroiditis(hypothyroidism stage),can significantly reduce the clinical symptoms and signs, lower A-TG,A-TPO levels,improve thyroid function,reduce the expression level of Th2 cytokine IL-6.Wenyang Huatan Chinese herbal medicine may balance Th1/Th2 cells in the immune system,affecting the expression levels of IL-6,IL-6 can induce antigen-specific B cells to secrete antibodies such as IgE and IgG1,and IgG1 constitutes A-TG and is the main components of the antibody,which may reduce the antibody levels of Pi Shen Yang Xu Xing Hashimoto’s thyroiditis(hypothyroidism stage) patients,drug safety,a significant effect, no adverse reactions.