| Objective: This study was designed to investigate acupuncture combined with Chinese medicine prescriptions(Green-e pill "Taiping Benevolent Dispensary Bureau" co Duhuojisheng "emergency preparedness daughter to party" subtraction) Governor of kidney cold ankylosing spondylitis treatment The clinical observation, through the establishment of the control group, the efficacy compared before and after treatment, trying to get meaningful research results, in order to better carry out clinical treatment of ankylosing spondylitis, broaden therapeutic thoughts.Method: 1, the test data: The clinical study of 60 cases selected medical records were from Wuhan City Chinese Medicine Hospital from January 2013 to January 2014 rheumatic pain outpatient and inpatient diagnosed with active AS(kidney Governor cold type) patients were scheduled to meet in this study inclusion and exclusion criteria. Including 55 cases of males and 5 females, using a random number method will be divided into two groups, one experimental group of 30 patients in the control group of 30 patients.2. Treatment: experimental group and control group were given oral celecoxib capsules, the specific use for each 0.2g, 1 times a day, as a basis for treatment. ①control group: 30 cases, on the basis of the treatment to the oral sulfasalazine enteric-coated tablets, the specific use: the treatment of the first week of each 0.25 g, 3 times a day; the second week of each 0.5g, day 3 second, from the third week of each 0.75 g, 3 times a day. ② test group: A total of 30 cases, on the basis of acupuncture to treat(specific operations:points to take the corresponding parts of lesions Jiaji back-shu points, Vital, Yaoyangguan, eight liao points, Yanglingquan, too River, Ashi use of reinforcing-reducing method, the needle for 30 minutes per treatment, 1 day, 10 times a course of two days rest between two courses) and Green-e Pills Duhuojisheng decoction(the basic prescription:Eucommia 15 g, Loranthaceae 15 g, Bugu fat 15 g, walnut 9g, Rehmannia 15 g, Achyranthes 9g, independent living 15 g, cinnamon 15 g, Gentiana 15 g, Asarum 3g, Chuanxiong 6g, wind 15 g, white peony root 15 g, Poria 15 g, an oral agent, a one-time daily Jianqu 400 ml, 200 ml each morning and evening meal, warm clothes) treatment, 12 weeks after the treatment were observed. 3. outcome measures: Patients underwent hospital safety index checks, including general physical examination, three conventional(blood, urine, feces), liver and kidney function and other biochemical markers examination; efficacy measure: ①The main symptoms: lumbosacral pain and discomfort may radiate to the buttocks or groin and thigh and lumbar limited activity in all directions, back pain, fatigue, joint pain, morning joint stiffness flu. ② main signs: 10 cm numerical pain score table, spine, thoracic mobility, Schober test, "4" and pillow wall test. ③ laboratory tests: erythrocyte sedimentation rate, C-reactive protein, HLA-B27, immunoglobulins(including IgA, IgM, IgG). ④ Radiology: sacroiliac joint radiographs. ⑤ clinical efficacy: the total efficiency, ASAS20 score. ⑥ adverse reactions: anorexia, abdominal pain, diarrhea, nausea and other gastrointestinal symptoms, alanine aminotransferase, WBC, platelet count and so on. 4. Statistical Methods: spss19.0 statistical software for statistical analysis. Use metering paired t test analysis data in the data set, using two independent sample t-test analysis of groups of data, Ridit rank test was used to analyze data and classified information is chosen X2 test. The P <0.05 as statistically significant critical, if P <0.05, the difference is considered statistically significant if P <0.01 considered statistically significant difference was extremely significant. Results: 1, clinical symptoms, the main signs and laboratory parameters were the main show: all clinical symptoms before and after treatment, the main signs and main laboratory parameters showed no significant difference(P> 0.05), the two groups before and after each treatment clinical symptoms, the main signs of contrast and major differences between laboratory indicators(P <0.05), in contrast to the clinical symptoms, the main signs and laboratory parameters after primary treatment, also has differences(P <0.05).2, sacroiliac joint radiographs radiology grade comparison: the two groups before treatment had no significant difference(P> 0.05) in the sacroiliac joint X-ray grade, after treatment sacroiliac joint X-rays show no significant change in classification difference(P> 0.05).3,compare the clinical efficacy: the experimental group and the control group, the total efficiency after treatment showed that the experimental group was 93.3%, 86.7% in the control group, the results compare with a difference between the two groups(P <0.05); ASAS20 score in terms of, treatment, Compared with the pre-treatment significantly improved(P <0.05), while in the control group was not statistically significant comparison(P> 0.05), and compare the two groups after treatment were significantly different(P <0.05).4, adverse reactions: the experimental group species and 5 patients had transient gastrointestinal symptoms(including anorexia, diarrhea, nausea), the control group, 10 patients had transient gastrointestinal discomfort(including anorexia, abdominal pain, diarrhea, nausea), 2 patients had leukopenia, 2 patients had mild alanine aminotransferase increased, there was a significant difference between the two groups of adverse reactions(P <0.05). Conclusion: The clinical trials showed that: the experimental group and the control group kidney Governor cold type AS are valid: test group in improving symptoms, signs, and biochemical indicators of clinical efficacy and reduces the incidence of side effects better than the control group. Acupuncture and Chinese herbal medicine effective prescription treatment of ankylosing spondylitis, the combination therapy of this disease have a better therapeutic effect and relatively fewer side effects. |
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