Study On Correlation Between Ischemic Cerebral Apopley Vulnerable Carotid Plaques And CXCL16 And Lp-PLA2

Objective: To detect carotid plaques and levels of CXC chemokine ligand 16(CXCL16) and lipoprotein-associated phospho lipase A2(Lp-PLA2) in patients with ischemic stroke and to discuss how ischemic stroke might be related to carotid plaques, level of CXCL16, level of Lp-PLA2 and other risk factors.Methods: 128 patients with ischemic stroke admitted by the Neurology Department in People’s Hospital of Qinghai Province from August 2013 to August 2014 belong to the case group. Control group includes 50 healthy people matching with the case group in gender and age, collected during the same time. The blood glucose, the blood lipid, CXCL16 and Lp-PLA2 of the two groups were determined under emptiness. The types of ischemic stroke and carotid plaques were recorded.Results: 1. There is no statistical difference between the case group and the control group in gender and age(P>0.05); there is statistical difference between the two groups in ethnic composition proportion, history of diabetes, history of hypertension, smoking history, drinking history and level of blood lipid(P<0.05). 2. There exists statistical difference in the level of CXCL16 and that of Lp-PLA2 between the LAA and the control group(P<0.05); there appears no statistical difference in the level of CXCL16 and that of Lp-PLA2 between the SAA and the control group(P>0.05); there is statistical difference in the level of CXCL16 and that of Lp-PLA2 between the LAA and the SAA(P<0.05). 3. The levels of CXCL16 and Lp-PLA2 in the control group, the non-plaques group, the stable plaques group and the unstable plaques group increased gradually; there is statistical difference in the level of CXCL16 and that of Lp-PLA2 between the control group and the stable plaques, as well as between the control group and the unstable plaques(P<0.05); there is no statistical difference in the level of CXCL16 and that of Lp-PLA2 between the control group and the non-plaques(P>0.05); there shows statistical difference in the level of CXCL16 and the level of Lp-PLA2 between the non-plaques and the stable plaques, so is there between the non-plaques and the unstable plaques(P<0.05); there is statistical difference in the level of CXCL16 and that of Lp-PLA2 between the stable plaques and the unstable plaques(P<0.05).Conclusions:1.The level of CXCL16 and that of Lp-PLA2 contribute to evaluating the risk of ischemic stroke. There is statistical difference in the levels of CXCL16 and Lp-PLA2 between the LAA and the SAA, while the levels are relatively higher in the LAA. 2.The increase of CXCL16 and Lp-PLA2 has a correlation with the vulnerability of carotid plaques. 3. 3.0T MRI of carotid plaques type is currently a new diagnostic method, it can distinguish between stable plaques and vulnerable plaques, and is of certain significance to guide clinical treatment.