Evaluation Of The Effectiveness Of Atomizing Inhalation Hypertonic Saline And Budesonide In Infants With Bronchiolitis

【Objective】To observe and explore the effectiveness of atomizing inhalation hypertonic saline(HS) and budesonide(BUD) in infants with bronchiolitis.【Methods】1、96 infants with bronchiolitis in the Affiliated Hospital of Yan’an University from September 2014 to March 2015 were selected;2、96 patients were randomized divided into two groups, 48 cases in the observation group and the control group;3、The observation group were treated with atomizing inhalation HS and BUD on the basis of conventional medicine treatment, while the control group were treated with conventional medicine;4、Cough relief time, wheeze disappearance time, crackles disappear time and length of hospital stay in two groups, as well as tidal volume, respiratory rate, time to peak ratio(t PTEF / t E) and peak volume ratio(VPTEF / VP)were recorded, and to evaluate the efficacy of two groups;5、The data was analyzed with SSPS 20.0 software,measurement date expressed as(X±S),using t-test,enumeration date expressed as percentage, using chi-square test the difference was statistically significant(p <0.05);【Results】1、Cough relief time, wheeze disappearance time, crackles disappear time and days of hospitalization in the bservation group were(5.7 ± 1.2) d,(4.2 ± 1.6) d,(5.1 ± 1.0) d and(8.4 ± 1.5) d, while was(7.2 ± 2.1) d,(5.5 ± 2.2) d,(6.8 ± 2.4) d and(11.4 ± 2.8) d in the control group, the difference was statistically significant(p <0.05);2、Before treatment, the difference of tidal volume, respiratory frequency, t PTEF / t E and VPTEF / VP in two groups was not statistically significant(p> 0.05), the degree of improvement after treatment in observation group was statistically more than in the control group(p <0.05); 3、The total efficiency of the observation group was 95.8%(46/48), the control group was 66.7%(32/48), the difference was statistically significant(p <0.05).【Conclusion】HS combine with BUD inhalation therapy can significantly improve lung function in children with bronchiolitis, relieve the clinical response, with a significant effect, thus is a safe and effective treatment for bronchiolitis.