The Relationship Between MTHFR Genotype Distribution And Coronary Heart Disease In H-type Hypertension Patients

Objective:To investigate the relationship between the gene polymorphism of methylene tetrahydrofolate reductase(MTHFR) site-specific mulation C667 T,homocysteine(Hcy) and coronary heart disease in H- type hypertension patients.Methods In this case-control study,we selected 60 H- type hypertension patients after Coronary angiography, All patients were divided into two groups,CHD group(n=33)and non-CHD(n=27). To detected MTHFR C677 T by gene chip technology,MTHFR genotype distributionb, the level of plasma Hcy was compared between the two groups.Results : In CHD and non-CHD group,the frequencies of MTHFR C677 T genotype were CC 27.3% vs 40.7%,CT 48.58% vs 48.2%,and TT 24.2% vs11.1%,The frequency of T allele and TT homozygotes in MTHFR in CHD group was higher than that in non-CHD group,but there was no significant difference between the two groups(P>0.05).②In CHD group,the plasma Hcy level(19.82±16.2umol/l) was higher than that(15.78±5.63umol/l) of the non-CHD group(P=0.022 <0.05).③The plasma Hcy concentration of individuals with TT genotype( 32.58±23.06umol/l) was higher than that of individuals with CC(14.64±6.93umol/l) and CT(14.76±3.65umol/l) genotype(P <0.05).Conclusions:The polymorphism of MTHFR C677 T are not related to coronary heart disease in H- type hypertension patients.MTHFR gene mutations can lead to high homocysteine levels.HHcy were all independent risk factors of CHD.