Study On The Changes Of Non-small-cell-lung-cancer TCM Syndromes In Different Stages Of Chemotherapy After Operation

Objective:Non-small cell lung cancer incidence rate is high, operation and chemotherapy is one of the mainly clinical treatment of non-small cell lung cancer,but operation is prejudicial,The chemotherapy drugs have strong toxicity and side effect.In order to further explore and improve the effect of chemotherapy after surgery on non-small cell lung cancer by TCM treatment,reduce the side effects of chemotherapy and operation,this research selected stage I-III non small cell lung cancer patients treated with chemotherapy after surgery,study on variation of traditional Chinese Medicine syndrome of different stages after operation and chemotherapy,expect to provide an objective basis for clinical treatment based on syndrome differentiation and further improve the conbined treatment of traditional Chinese medicine and western medicine effect of lung cancer.Methods:We collected 60 stage I-III non-small cell lung cancer patients who treated with chemotherapy after operation as clinical observation.Recorded the general information of these patients,the chemotherapy regimen which they chosen and the laboratory test results. Every 2 cycles of chemotherapy were divided into a period of chemotherapy.The syndrome differentiation is in progress through proposed diagnostic criteria.Then we collected and recorded the data of this research.Finally,using the SPSS17.0 to analyze the data.Results:(1)After operation,the constituent ratio of qi deficiency and phlegm dampness type decreased to 25%.Syndrome of qi stagnation and blood stasis increased to 51.7%.(2)Lung and spleen deficiency type accounted for 60% after the first stage of chemotherapy,after the whole chemotherapy was 8.3%.Qi stagnation and blood stasis type accounted for 8.3% after the first stage of chemotherapy,then decreased to 3.3%and 1.7% gradually.The proportion of deficiency of both qi and Yin Syndrome risen from 8.3% to 20% finally.The proportion of qi deficiency and phlegm dampness type decreased from 20% to 15%.After chemotherapy,the statistics found that yang deficiency of spleen and kidney syndrome had an obvious increasing trend. Theproportion of yang deficiency of spleen and kidney risen from 3.3% to 55% rapidly.(3)The level of serum tumor markers have statistical significance at different treatment stages(P<0.05).With the progress of treatment,the level of serum tumor markers of each syndrome type of traditional Chinese Medicine has a declining trend.(4)The white blood cell counts in blood after chemotherapy are lower than the counts after operation(P<0.05).Conclusion:(1)The number of patients with qi deficiency and phlegm dampness syndrome is decreased by operation.But the number of patients with qi stagnation and blood stasis increased after operation.(2)The diseased region of NSCLC is lung, the main syndrome is deficiency and damage of lung-QI.At the beginning of chemotherapy, the spleen and stomach hurt is grievous injuried,that leads to pulmonosplenic asthenia.At later stage of chemotherapy,the kidney is mainly damaged,that leads to decline of kidney-YANG and phlegm stagnation.(3)With the progress of chemotherapy,the level of serum tumor markers of each syndrome type of traditional Chinese Medicine has a declining trend.Judged by monitoring the changes of CEA, SCC, CA125, CA153 levels contribute to the efficacy of non small cell lung cancer after operation and chemotherapy.(4)Chemotherapy can decrease white blood cell counts,even let the counts be much lower than the normal level,while operation treatment has little effect on the counts.