Clinical Research Of Postoperative Analgesia Using Oral Administration Of Oxycodone Acetaminophen And Celecoxib In Laparosopic Cholecystectomy

Objective To investigate the safety and the efficacy of postoperative analgesia using oral administration of oxycodone/acetaminophen and celecoxib in laparosopic cholecystectomy.Methods 60 patients undergoing laparosopic cholecystectomy were divided into three groups randomly. They were oxycodone/acetaminophen group (group A), celecoxib group (group B) and placebo-controlled (Capsule Vitamine E) group (group C). Each group was 20 cases. Patients in group A were given one tablet of oxycodone/acetaminophen (5mg acetaminophen and 325mg oxycodone in each tablet) 8 hours prior to surgery, and then one tablet was taken at the time of 6 hours after operation. Oxycodone/acetaminophen was administered 1 tablet thrice a day (in the morning, noon and evening) at the following two days. Patients in group B were given two capsules of celecoxib (200mg/each capsule) 8 hours prior to surgery, and then one capsule was taken at the time of 6 hours after operation. Celecoxib was administered 1 capsule twice a day(in the morning and evening) at the following two days. 100mg tramadol was provided for all the groups by intramuscular injection if the patients still felt pain. The visual analogue scale (VAS) at rest and in moving, characters of pain,sedation score, tramadol consumption, gastrointestinal function and the side effects were observed and recorded at the time of 30min after waking up, 6 hours, 12 hours, 24 hours and 48 hours after surgery.Results The VAS in group A and group B were lower than that in group C at the time of 30min after waking up, 6 hours,12 hours and 24 hours after surgery during the rest (P<0.05), the VAS in group A and group B showed no significant difference at the same time during the rest (P>0.05). The VAS in group A and group B were lower than that in group C at all the time when moving. The VAS in group A was lower than that in group B at the time of 12 hours, 24 hours and 48 hours after surgery (P<0.05). The incidences of non-incisional pain(visceral pain and shoulder pain) were 60%,65% and 75% respectively in three groups, which were not different significantly (P>0.05). The tramadol consumption in group A and group B were significantly lower than that in group C (P<0.05). We did not use any tramadol in group A and group B. There was no significant difference in th side effects among three groups (P>0.05).Conclusions It was effective and safe that oral administration of oxycodone/acetaminophen and celecoxib in perioperative analgesia after laparoscopy cholecystectomy. The analgesic effective of Oxycodone/acetaminophen was better than that of celecoxib when patients moving.