The Changes Of Cerum Marker And Affecting Factors In Poststoke Depression Patinents

Objective Through detecting the level of serum C- reactive protein(CRP), insulin-like growth factor 1(IGF 1) and the positive rate of glutamic acid decarboxylase antibody(GAD- Ab), combined with the risk factors, NIHSS score and the lesion site in poststroke depression patients, to analyze the pathology process of poststroke depression that may be related to inflammation factor, abnormal immunity and dysbolism of glutamate and explore the pathogenesis and correlated factors of poststroke depression in depth.Method 65 inpatient patients of neurology in our hospital who had a poststroke stress were selected(HAMD score 8-23), of all these patients, 21 got a seriously stress, and there were 26 who had a diabetes in together. We also selected 65 patients who had a stroke but without stress in the contemporaneity as the control group. All patients were graded with HAMD-17 during the inpatient period and 1 month after morbid. All selected patients had be compared with general information and risk factors and detected the level of CRP,IGF-1 and the positive rate of GAD-Ab in the first 2 weeks;To analyz the lesion position and the NIHSS score in the early stage.Result The level of C-reaction protein, insulin-like growth factor-1 in poststroke depression patients were higher than the control group, and had no significant differences(P>0.05), but those patients who had a seriously depression and complicating diabetes had an obviously raise than the control group, and had a significant difference compared with the control group(P<0.05). The positive rate of Glutamic acid decarboxylase antibody in blood serum had no differences between groups(P>0.05). Poststroke depression had evidently relativity with lesion in frontal lobe and cerebral ganglia,complicating diabetes and a high NIHSS score in the early stage of the disease, and no significant relativity with other risk factors, such as hypertension, coronary heart disease etc.Conclusion Inflammatory reaction, abnormal immunity and dysbolism of glutamate may participate in the pathologic process of poststroke depression; Diabetes, a high NIHSS score in the early stage of the disease, lesion in frontal lobe and cerebral ganglia may be related to poststroke depression. Determination of the level of CRP and IGF-1 in blood serum had a significant means in estimating of seriously poststroke depression patients.