Relationship Between Uric Acid, High Sensitivity C Reactive Protein And Ambulatory Arterial Stiffness Index In Patients With Non-dipper Hypertension

Objective:To investigate the relationship between uric acid, high sensitivity C reactive protein and ambulatory arterial stiffness index in patients with non-dipper hypertension. Methods:252 patients admitted to our hospital from January 2013 to January 2014 were divided into dipper hypertension group(n=81) and non-dipper hypertension group(n=95) and other 76 patients of normal blood pressure served as the control group. All groups were tested uric acid and high-sensitivity C-reactive protein, gave 24 h ambulatory blood pressure monitoring. The relationship between uric acid, high-sensitivity C-reactive protein and ambulatory arterial stiffness index were analyzed. Results:Compared with dipper hypertension group and the control group, non-dipper hypertension group had long pathogenesis, high systolic blood pressure, low diastolic blood pressure and big pulse pressure(P<0.05). Uric acid, high-sensitivity C-reactive protein and ambulatory arterial stiffness index of non-dipper hypertension group were significantly higher than others(P<0.05), and uric acid(B=0.008) was a risk factor for non-dipper hypertension. Uric acid(r=0.436,P <0.001) and high-sensitivity C-reactive protein(r=0.603,P <0.001) were positively correlated with ambulatory arterial stiffness index. Conclusion:With the increase of high-sensitivity C-reactive protein and uric acid, ambulatory arterial stiffness index becomes higher and has more serious degree of arteriosclerosis in patients with non dipper hypertension.