Correlation Of The Serum Sex Hormone Levels And Estrogen Receptor Expressions With Papillary Thyroid Carcinoma

Objective:To explore the influence of serum sex hormone levels, estrogen receptor expressions in papillary thyroid carcinoma and the correlation with tumor biological indicators, in order to make clear their clinical and biological significance. Methods:30 cases with` papillary thyroid carcinoma patients were collected, as the case group, and 30 patients with nodular goiter matched the same with age, gender and menstrual status, as control group, which were resecting thyroid gland in April 2014 to October of Third People’s Hospital of Shanxi Province, Datong. Two groups of patients were detected serum estradiol(E2), progesterone(P), luteinizing hormone(LH) and follicle-stimulating hormone(FSH) levels by chemiluminescence immunoassay before operation, and expressions of estrogen receptor(ER) by immunohistochemical post-operation, in order to analyse the difference of estrogen receptor expressions and serum sex hormone levels, to explore its correlation with tumor biological indicators. Results:1. The average concentration of estradiol, progesterone, luteinizing hormone, follicle stimulating hormone in thyroid papillary carcinoma patients are higher than the control group, but the difference had no statistical difference(P>0.05).2. Levels of estrogen in women patients of papillary thyroid carcinoma were significantly higher than that of nodular goiter group(P<0.05), levels of progesterone in the childbearing age women lower than that in controls(P<0.05).3. The positive expressions rate of Estrogen receptor in papillary thyroid carcinoma and nodular goiter organization was 83.3%, and 43.3%, respectively, with significantly statistical difference(P=0.000).4. In 30 cases of patients with thyroid papillary carcinoma, estrogen receptor positive rate of less than 45 years old, more than 45 years old group is 90.9%,78.9% respectively, that of tumors diameter greater than 1 cm, less than 1 cm group is 90.9%, 78.9%, with and without lymph node metastasis group is 71.4%,86.9%, tumor stage for Ⅰ Ⅱ, Ⅲ Ⅳ period is 87.5%,66.7%, there were no statistically significant difference.No correlation was found between estrogen receptor expressions and patients age, carcinoma organization size,lymph node metastasis, tumor TNM stage(P>0.05).5. The level of progesterone, luteinizing hormone With lymph node metastasis, tumor staging for Ⅲ, Ⅳ menopause patients in thyroid papillary carcinoma is significantly higher than without lymph node metastasis, tumor stage for Ⅰ, Ⅱ period(P<0.05).6. Estrogen receptor expressions were found no significant relationship between sex hormone levels(P>0.05). Conclusions:1. Estrogen and ER expressions may promote the occurrence of thyroid papillary carcinoma, can be used as reference indexes to identify benign and malignant thyroid tumors, but nor to prognosis of carcinoma.2. Progesterone may have a protective effect on thyroid papillary carcinoma in Childbearing age.3. Progesterone, luteinizing hormone may be associated with invasion and metastasis of carcinoma.4. The expressions of ER are no necessarily related with sex hormone levels for thyroid papillary carcinoma patients.