The Relationship Between The Carotid Intima-media Thickness And Cerebral Microbleeds In Patients With Cerebral Infarction

Objective Atherosclerosis is one of the important reasons for the small blood vessels damage.Cerebral microbleeds is one of the most important performance in cerebral small vessel disease.In this paper,a study about the relationship between the carotid atherosclerosis and the prevalence and the locations of cerebral microbleeds was investigated,throught the observation of the carotid intima-media thickness and the prevalence and locations of cerebral microbleeds.Methods Sixty-six patients with acute non-cardioembolic ischemic stroke who were hospitalized in Department of Neurology of Fu Jian Union Hospital from January 2014 to June 2015 were successively recruited.All patients were taken a blood test on an empty stomach in the next 24 hours,and underwent magnetic resonance imaging and carotid artery check in the next seven days.The patients were divided into two groups according to whether there are CMBs or nor on GRE-T2*WI:CMB group(forty-five cases) and non-CMB group(twenty-one cases).Clinical baseline data,biochemical variables(including Triglycerides, Cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol,frbrinogen,uric-acid,fasting plasma glucose,Hypersensi-tive,C-reaction protein,homocysteine,etc.),carotid intima-media thickness,the numbers and locations of CMBs in GRE-T2*WI between the two groups were recorded detaildely.The risk factors of the CMBs were analyzed with the Logistic multivariable regression,and the association between the carotid intima-media thickness and CMBs wer futher analyzed.All of our findings were checked and approved by attending physicians using the Brain Observer Micro Bleed Scale Stroke(BOMBS) to improve interrater agreement about CMBs.CMBs were classified as three grades:mild group(one to two),moderate group(three to ten),severe group(more than ten);CMBs were classified cortical or subcortical,basal ganglia or thalamus,subtentorium and mixded. Results:45(68.20%) patients were CMBs positive on GRE-T2*WI.In multivariate logistic regression analysis,hypentension white matter lesions and the low density lipoprotein cholesterol were independent factors increasing the risk of CMBs(P<0.01);CIMT were in CMBs group(0.96±0.21mm) were higher compared with the non-CMBS group(0.81±0.13),the differentce was statistically significant(P<0.05).The CIMT were different as the different degrees of the CMBs: mild group(0.87±0.22mm),moderate group(0.95±0.20mm),severe group(1.16±0.05mm).The CIMT of the severe group were higher than the mild group(P=0.036) and the moderate group(P=0.009);The CIMT with different locations of the CMBs: subtentorium(1.17±0.08mm);basal gangliaor thalamus(0.93±0.22mm);cortical or subcortical(0.96±0.15mm),and mixded(0.94±0.26mm);the CIMT of subtentorium were higher than the basal gangliaor thalamus groups, the differentce was statistically significant(P<0.05);No statistical significance between other groups(P>0.05).Conclusion:Hypentension,white matter lesions, the low density lipoprotein cholesterol were independent factors increasing the risk of CMBs.The CIMT in CMBs group were higher than non-CMBs groups,and present a positive correlation. The CIMT of subtentorium were higher than the basal gangliaor thalamus groups.There were no relationship between the CIMT and the locations of CMBs in other groups.