Risk Factors For Bronchopulmonary Dysplasia In Neonates With Respiratory Distress

Objective:To identify the risk factors for bronchopulmonary dysplasia (BPD) in neonates with respiratory distress.Methods:Data from 287 neonates with RDS who were hospitalized over 28 days were analyzed respectively.Results:Of the 287 neonates,131 developed BPD (45.64%).In univariate analysis, gestational age, birth weight, hospitalization duration, maternal age, cesarean section, the times of pulmonary surfactant(>2 times),the dose of pulmonary surfactant, the positive rate of sputum cultures, the mechanical ventilation, the mode of mechanical ventilation, the inhaled oxygen volume concentration, the duration of mechanical ventilation, the duration of oxygen, ventilator-associated pneumonia, pulmonary hypertension, patent ductus arteriosus (PDA),the survival rate and the mortality were all associated with an increase in the incidence of BPD(P<0.05). No significant differences were found in multiple pregnancy, sex, the first minute of Apgar score, the hospitalization time, the fetal distress, premature rupture of membrane, prenatal glucocorticoid, gestational hypertension, gestational diabetes, the rate of pulmonary surfactant, the time of pulmonary surfactant, the first blood gas analysis scores after birth, combined with Neonatal necrotizing enterocolitis (NEC),air leak, septicemia, Retinopathy of prematurity(ROP), intracranial hemorrhage, pneumorrhagia between the two groups(P>0.05).Multivariate logistic regression model showed the risk factors for BPD were duration of oxygen and pulmonary hypertension.Conclusion:Preventing the preterm delivery,shortening the duration of oxygen and preventing the pulmonary hypertension were key factors to reduce BPD in neonates with RDS.