The Research Of The Relationships Between Fibulin-5 And Severity And Prognosis Of Patients With Acute Intracerebral Hemorrhage

Objective To detect plasma Fibulin-5 levels in patients with acute intracerebral hemorrhage, evaluate severity and prognosis of the patients, and investigate the relationships between plasma Fibulin-5 levels and severity or prognosis of ICH patients.Methods In 68 cases of patients with acute cerebral hemorrhage, plasma Fibulin-5 levels both within 72 hour and 7th day were detected by using Enzyme-linked immunosorbent assay method(ELS A), cerebral hemorrhage volume was caculated, the levels of consciousness were evaluated by using Glasgow coma scale scale (GCS) score, patients’ neurologic deficits were evaluated by using the United States national institutes of health stroke scale (NIHSS) score; body temperature, blood pressure, blood sugar, white blood cell count, platelet, blood lipids, blood coagulation function, hs-CRP, CRP and other general laboratory indexes were collected. Evaluating 30-day mortality of patients with acute cerebral hemorrhage, and assessing the neural functional recovery after 3 months by using modified Rankin scale to judge the prognosis of the disease. Compare the general laboratory indexes between groups devided according to severity and prognosis. Find the relationships between Fibulin-5 levels and the disease’s severity and prognosis.Reults Plasma concentrations of Fibulin-5 with acute cerebral hemorrhage within 72 h are higher than normal control group (64.69± 27.41 ug/L vs 40.98 ±4.94 ug/L, t= 6.44, P= 0.00), plasma concentrations of Fibulin-5 on 7th day are higher than plasma concentrations of Fibulin-5 within 72 h (84.27±.24 ug/L vs 58.06+ 25.36 ug/L, P= 0.00). Plasma concentrations of Fibulin-5 within 72 h correlated positively with hematoma volume (r= 0.819, p< 0.01),and NIHSS score (r= 0.50, p< 0.01), negatively with GCS score (r= 0.55, p< 0.01)on admission. Concentrations of Fibulin-5 were higher in patients who died within 30 days than in 30 days survivors (99.98±38.70ug/L vs 59.31±20.94ug/L, t=-4.77, P=0.00). Single factor logistic regression analysis results of 30-day mortality show that hamotama vulume and plasma Fibulin-5 levels within 72 h, NIHSS score, GCS score for patients with acute cerebral hemorrhage are prognostic predictors of mortality in 30-day, which can predicte mortality in the near future, and general laboratory indexes suck as white blood cells, blood glucose, triglycerides cannot predict mortality in 30-day. Plasma concentrations of Fibulin-5 in patients who have poor outcomes of nerval function after 3 months are also higher than in patients who have good outcomes(69.66±24.17ug/L vs 53.16±16.18ug/L,P< 0.01); Single factor logistic regression analysis results show that the plasma Fibulin-5 levels, hematoma vulume, NIHSS score, GCS score are prognostic predictors of neural functional recovery after 3 months, and general parameters such as white blood cells, blood glucose, triglycerides cannot become neural functional prognostic predictors.Conclusion Plasma concentrations of Fibulin-5 at early acute cerebral hemorrhage are increased, and the plasma concentrations of Fibulin-5 are higher on 7th d. Concentrations of Fibulin 5 correlated positively with hematoma volume, NIHSS score, correlated negatively with GCS score, which are predictors of mortality in 30-day and predictors of nervous functional recovery after 3 months.