Association Of Two Polymorphisms RS1061170 And RS1410996 In Complement Factor H With Age-Related Macular Degeration In Asian Population:a Meta-Analysis

Background:With the increasing number of studies indicating that two single nucleotide polymorphisms (SNPs) rs1061170 and rs1410996 in complement factor H (CFH) might be associated with the susceptibility to age-related macular degeneration (AMD), the exact association still remains uncertain. Thus we conducted a meta-analysis to systematically summarize and clarify the association between the two SNPs and AMD risk particllarly in Asian population.Objective:To assess the association of two polymorphisms in complement factor H with age-related macular degeneration in Asian population.Methods:A systematic search of studies on the association of two SNPs with susceptibility to AMD was conducted in PubMed, Embase and Web of science. Summary odds ratios (ORs)and 95% confidence intervals (CIs) of allele contrast and genotype contrast were estimated using the random or fixed effects model. The Q-statistic test was used to identify heterogeneity, and the funnel plot was adopted to evaluate publication bias. A total of 19 case-control studies on rs 1061170 and 8 studies on rs1410996 were included.Results:Clearly a significant increased trend of AMD was observed in the rs1061170(T versus C:OR= 1.91,95% CI 1.71-2.13, PH= 0.029; TC versus CC:OR= 2.11,95% CI 1.30-3.42, PH= 0.792; TT versus CC: OR= 3.90,95% CI 2.45-6.22, PH= 0.774; TC/TT versus CC:OR= 3.39, 95% CI 2.13-5.41, PH= 0.691; TT versus TC/CC.OR= 1.74,95% CI 1.31-2.31, PH ＜0.001). Similarily, the rs1410996 polymorphism also showed a rising AMD tendency(T versus C:OR= 1.48,95% CI 1.17-1.87, PH<0.001; TC versus CC:OR= 1.52,95% CI 1.13-2.04, PH= 0.002; TT versus CC:OR= 2.10,95% CI 1.27-3.49, PH<0.001; TC/TT versus CC: OR= 1.37,95% CI 0.85-2.21, PH<0.001; TT versus TC/CC:OR= 1.68, 95% CI 1.21-2.33, PH= 0.003). What’s more, subgroup analysis revealed that both of the two polymorphisms indicated a high risk of nAMD in Asian population.Conclusion:This meta-analysis suggested that CFH rs 1061170 and rs 1410996 polymorphisms were absolutely associated with AMD risk, both of whom demonstrated a higher susceptibility to AMD, especially to nAMD. However, the results of rs 1410996 should be interpreted with caution due to limited sample and heterogeneity. Large-scale and well designed studies are needed to validate our findings.