| Target: To observe the curative effect of NXKKFY II oral liquid in treating coronary heart disease(phlegm and blood stasis and Qi deficiency syndrome) and the effect on blood lipid and to explore its clinical significance.Methods 1, Group: Randomly select 72 cases of patients with coronary heart disease(phlegm and blood stasis and Qi deficiency syndrome), the patients were 40 years-70 years old, and the duration of disease was 9 months-13 years. The 72 cases were randomly divided into the observation group and the control group,36 cases in each group. Before the clinical process, the observation group and the control group were compared with the gender, age, disease course, symptoms of angina, ECG, treadmill exercise test, blood lipids, and the difference between the two groups was not statistically significant(p>0.05). 2, Give medicine: The observation group would be given NXKKFY II oral liquid( by traditional Chinese medicine preparation room of Jilin University First Hospital, Each 100 ml contains 117.5g crude drug, 4 degrees Celsius refrigerator preservation, the application of heating to warm) Each dose of 100 ml, twice every day, oral administration. Isosorbide Mononitrate Tablets(Shandong lunanbeite Pharmaceutical Co. Ltd, was given to the control group,20mg / tablets, approval number: Chinese medicine quasi word H10940039), 20 mg once, twice every day, oral administration. Observation group and control group were 28 days for a course of treatment. 3, Observation index: The vital signs of the two groups were observed during the clinical trial.(temperature, pulse, respiration, blood pressure), clinical manifestations, before and after treatment of blood routine, urine routine, liver function(ALT, AST, GGT), renal function(BUN, Cr), blood glucose, blood lipid, angina pectoris, ECG curative effect, treadmill exercise trials on efficacy. Two groups of patients were compared before and after treatment of angina pectoris, ECG, treadmill exercise test, blood lipid changes.Results Two groups of patients with angina pectoris, electrocardiogram curative effect before and after treatment, the difference has statistical significance(P<0.05), after treatment than before treatment were significantly improved, After treatment, there was no significant difference between the two groups(P>0.05), There was no significant difference between the observation group and the control group;Two groups of treadmill exercise testing in patients with exercise time before and after the treatment difference has statistical significance(P<0.05), after treatment than before treatment were significantly improved, after treatment between the two groups compared with statistical significance(P<0.05) and observation group curative effect surpasses the control group; Observation group of patients with blood lipids(total cholesterol, triglyceride, low density lipoprotein cholesterol) before and after treatment, the differences have statistical significance(P<0.05), After treatment than before treatment is significantly improved, the control group, the above indexes before and after treatment difference no statistical significance(P>0.05), after treatment between the two groups of blood lipids(total cholesterol, triglyceride, low density lipoprotein cholesterol) compared with statistical significance(P<0.05),The observation group curative effect surpasses the control group, the two groups of patients with blood lipid(high density lipoprotein cholesterol(HDL-C) before and after treatment had no obvious change. In the control group, there were 2 patients with mild headache, but there was no suspension test, No adverse reactions occurred in the observation group.Conclusions NXKKFY II oral liquid significantly improves the coronary heart disease(phlegm and blood stasis and Qi deficiency syndrome) in patients with symptoms of angina, improve ECG ischemia degree and efficacy and Isosorbide Mononitrate Tablets quite; NXKKFY II oral liquid can significantly prolong the time of the movement of the coronary heart disease(CHD) exercise treadmill test, Improving the tolerance of myocardium to ischemia and hypoxia, curative effect is better than the Isosorbide Mononitrate Tablets; NXKKFY II oral liquid has obvious lipid-lowering effect. The efficacy of NXKKFY II oral liquid is definite, no adverse reactions. To sum up: NXKKFY II oral liquid can effectively relieve angina symptoms in patients with coronary heart disease, ECG, treadmill exercise test and other related examination results were significantly improved, improve the quality of life of patients, improve the long-term prognosis of patients with coronary heart disease, in the regulation of blood lipids have a certain potential position. The efficacy of NXKKFY II oral liquid was definite and no adverse reactions. |
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