Analysis Risk Factors For Hyperamylasemia After Endoscopic Retrograde Cholangiopancreatography

Objective:To investigate the risk factors for the development of postendoscopicretrograde cholangiopancreatography pancreatitis and hyperamylasemia(PEPH) after endoscopic retrograde cholangiopancreatography(ERCP).Methods:The clinical date of 233 patients who underwent therapeutic ERCP from January 2012 to December 2014 in our hospital and met the inclusion criteria were analyzed respectively. Basic information including age,sex,drinking history,single stone, triglyceride,and nationality was extracted, and detailed information on intraoperative procedure, intraoperative diagnosis,and complications for ERCP was carefully recorded. Chi- squaretest was applied for comparison of categorical date between groups, and Logistic regression analysis were applied to determine the risk factors for the development of PEPH. Results:The incidence of PEPH was 26.6%(62/233).Univariate analysis showed that female sex(2? =3.320, P =0.045),drinking history(2? =6.108, P =0.010),common bile duct stenosis( ?2 =5.767, P =0.012),single stone(2? =9.121, P=0.02), juxta-ampullary duodenal diverticula(2? =28.170, P <0.001),and abnormal triglyceride( ?2 =57.717, P <0.001) might be risk factors of PEPH,and these factors differed significantly between the two groups. Multivariate analysis showed that female sex(OR=1.161, P=0.025) drinking history(OR=2.360, P=0.010), common bile duct stenosisi(OR = 2.163, P = 0.012),juxta-ampulary duodenal diverticula(OR=5.502, P <0.001),and abnormal triglyceride(OR=12.924,P <0.001) were independent risk factors for PEPH.Conclusion:Female sex,drinking history,common bile duct stenosis,juxta-ampulary duodenaldiverticula,and abnormal triglycerideare independent risk factors for PEPH.