Trends Of Clinicopathological Features And Diagnosis And Treatment Methods For Operative Female Patients With Breast Cancer In XinJiang Uygur Autonomous Region: A Single Center Study

Objective: To review the clinical pathological characteristics and diagnosis and treatment patterns of 2001~2010 female patients with breast cancer in Xinjiang area, and to examine the effectiveness of the prevention and treatment of breast cancer in Xinjiang region during the past 10 years, and to provide a clinical basis for the prevention and treatment of breast cancer in Xinjiang region. Methods: the clinical data and follow-up data of 1024 patients with operable breast cancer were retrospectively analyzed in cases of breast cancer patients who were operated on in Xinjiang preparatory University Affiliated Cancer Hospital from 2001~2010 to 2006~2010. Results: compared with 2001~2005, the patients with operable breast cancer were 215% and 1024, the average age of onset was47.2±8.7 years old. 2006~2010 early breast cancer(0~I) detection rate of 21.0% compared with 16.2% of 2001~2005 significantly increased(P<0.05), while the proportion of patients with stage III breast cancer significantly decreased from 30.7% to 19.0%(P<0.05),the proportion of in situ cancer increased from 3.2% to 5.1%. 2001~2005 axillary lymph node metastasis rate was 56.2%, 2006-2010 decreased to 46.9%(P<0.05). Local recurrence and distant metastasis rate also showed a downward trend, 2001-2005 and2006~2010 were 29% and 22.7%(P<0.05). The overall survival rate and disease-free survival rate at 5 years after operation were 79.7% and 71.0% for 2001~2005, 86.7% and77.3%(P<0.05), respectively. And(2006~2010). In the period of breast cancer modified radical mastectomy is always the main operation way, 2001~2005 and 2006~2010 were81.1% and 87.3% respectively, the proportion of breast conserving surgery increased gradually, there were 3.2% of 2001~2005 years increased to 9.1% of 2006~2010. The proportion of patients who received neoadjuvant chemotherapy,preoperative empty coreneedle biopsy, Immunohistochemistry and the examination rates at admission by breast ultrasound mammography and breast MRI and the rate of the duration from getting conscious of lump to seeking treatment ≤1 month(P<0.05).Conclusion:2001~2010years,the hospital admitted that the number of breast cancer cases increased significantly,improve the early detection rate and standardized application of comprehensive diagnosis and treatment measures are the key to improve the prognosis of patients.