Infection Of High Risk HPV And Its Relationship With The Expression Of P53 Protein In Primary Lung Cancer

Objective: To investigate the expression levels of high risk human papillomavirus(HPV) and p53 protein in primary lung cancer, and explore their intercorrelation and the role in the progression of primary lung cancer. Methods: We collected the data about 51 cases who received surgical excisionin with primary lung cancer and 26 cases with lung benign lesions from April 2014 to June 2015, detected their infected situation of high risk HPV in bronchial epithelial cells of primary lung cancer and benign lung lesions by Hybrid Capture 2 method, in addition, the expression of p53 protein in the tissues of primary lung cancer and benign lung lesions were detected by immunohistochemistry.Results: The detected rate of high risk HPV in the primary lung cancer patient’s bronchial epithelial cell was 15.69%, and the rate in the lung benign disease patients was 0%, the difference was statistically significant(P<0.05); the positive rate of p53 protein in primary lung cancer tissues was 52.94%, which was significantly higher than that in lung benign lesion tissues, and the rate in lung benign lesion tissues was only 11.54%, the difference was statistically significant(P<0.001). In addition, the positive rate of the p53 protein in the HPV positive group was 75%, which was higher than the negative group, and the rate in the negative group was only 48.84%, the difference was statistically significant(P<0.05). The high risk HPV infection in primary lung cancer was related to pathological types and clinical stage(P<0.05), but was not related to gender, national, age, lymph node metastasis, and smoking history(P>0.05). The p53 protein expression in primary lung cancer was related to pathological types, smoking history and clinical stage(P<0.05), but was not related to gender, national, age, and lymph node metastasis(P>0.05). Conclusion:The infection of HPV may be one of the risk factors which result in the occurrence of primary lung cancer; the infection of HPV may promote lung cancer occurrence and development through making p53 protein inactivate.