Study Of The Chemotherapy-induced Retrospective And Prospective Memory Impairment Of Triple-negative Breast Cancer

Objective In recent years, the studys about chemotherapy related cognitive impairment(CICI) on the patients with breast cancer haven been more and more. Some studies have found that CICI on the patients with breast cancer has seriously affect the patients quality of life. One of the most prominent performance is the memory impairment after chemotherapy on the patients with breast cance. A large number of studies have found that the presence of memory impairment showed heterogeneity after chemotherapy of breast cancer. But the specific mechanism is still don’t understand. Whether it is related to molecular typing is unclear. The objective of this study is to investigate the differences of memory impairment after chemotherapy between triple-negative breast cancer(TNBC) and non-triple-negative breast cancer(NTNBC), and to understand the characteristics of chemotherapy-induced retrospective(RM) and prospective memory(PM) impairment of TNBC.Methods Sixty breast cancer patients of the oncology department of the second affiliated hospital of Anhui medical university from the March 1, 2014 to June 30, 2015 were taken as the observation group, who had received adjuvant chemotherapy after operation, including 30 cases of TNBC(27 cases of invasive ductal carcinoma, 3case of invasive lobular carcinoma) and 30 cases of NTNBC(25 cases of invasive ductal carcinoma, 5 case of invasive lobular carcinoma). In addition, 60 cases of healthy women volunteers with matched age and education level were also selected as the control group.All participants were administered with mini mental state examination(MMSE), retrospective memory(RM) and prospective memory(PM) questionnaires.Results Compared with the healthy control group, the MMSE, RM and PM scores of observation group were respectively(27.08 ± 1.37) points,(17.97 ± 4.34) points and(18.78 ± 4.24) points; and the differences of them were statistically significant(t=2.880, ﹣6.486, ﹣8.645; P<0.05). Compared with the NTNBC group, the MMSE, RM and PM scores of TNBC group were respectively(26.50 ± 1.67) points,(19.30 ± 2.60) points and(20.33 ± 3.50) points; and the diifferences of them were statistically significant(t=3.624, ﹣2.483,﹣3.018; P<0.05).Conclusion Patients with breast cancer exist different extents of RM impairment and PM impairment after chemotherapy, and the retrospective and prospective memory damage of patients with TNBC are obviously higher than those of patients with NTNBC(P <0. 05), which imply that different expressions of hormone receptor may be associated with the occurrence of memory impairment after chemotherapy of breast cancer patients.