| Objective: To compare the outcomes of robotic-assisted laparoscopic and laproscopic radical prostatectomy by meta-analysis. Methods: Databases including PubMed, Cochrane library, Web of Science, CNKI, VIP and Wanfang were searched fo r controlled studies comparing laparoscopic radical prostatectomy(LRP) and robotic-assisted laparoscopic prostatectomy(RALP) for prostatic neoplasms. Primary outcomes were summarized and compared. Results: Two randomized controlled trials an d 15 non-randomized controlled trials were included in this analysis. These studies included a total of 4273patients: 2190 cases of RALP and 2083 cases of LRP. The meta-analysis showed no difference between RALP and LRP in operation time, 3-year biochemical recurrence-free survival rates, positive surgical margin rate, 12-month urinary continence and potency recovery(P>0.05). But RALP is better in operative blood loss, transfusion rate, intraop open conversion, rectal injury, anastomotic leakage, urinary retention, urinary continence at 3-month, 6-month as well as e rectile function at 3-month, 6-month and 12- month. In terms of urinary tract infection, LRP group than RALP group(P<0.05). Conclusions: Robot-assisted laparoscopic radical prostatectomy is a safe and effective method, However, the studys have publication bias and some sample size is small, the large sample of high quality clinical trials of RCT are still needed for further confirmation. |
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