Higher Mean Arterial Pressure Is Associated With Increased Survival And Better Neurological Outcomes In Post-cardiac Arrest Syndrome

Objectives:We prospected measuredmean arterial pressure(MAP) over time during the post-resuscitation period and tested its association with in-hospital survival and neurological outcome. Measurements : Our research protocol measured blood pressure noninvasively every 1 hour for the first 12 hours after resuscitation,Age,Sex,The mean time to ROSC,Rhythm and so on. We calculated the 0- 6 /6-12 hourtime-weighted-MAP and used multivariable logistic regression to test the association betweentime-weighted-MAP and in-hospital survival/better neurological outcomes. Results:Among 144 patients, 112(77.8%) experienced in-hospital survival. The association between 0-6h/6-12 hMAP and outcome appears to have a threshold effect at time-weighted-MAP value of 80/85 mmHg. In the first 6hours,this threshold(MAP> 80mmHg) had the strongest association with in-hospitalsurvival.(OR 6.114,95%CI1.859–20.303); In the second6 huors,this threshold(MAP > 85 mm Hg) had the strongest association with in-hospital survival(OR 11.505,95%CI3.552–37.264). But,this threshold(MAP > 80 mm Hg or 85mmHg)was not associated with good neurologic outcome. Conclusions: We found that,in the first 6 hours of PCAS, time-weighted-MAP was associated with in-hospital survival at a threshold of MAPgreater than 80 mmHg. In the second 6 hours of PCAS the threshold is greater than 85 mm Hg.But both MAP greater than 80 mm Hg(0-6h)and greater than 85 mmHg(6-12h)were no associated with neurologic outcome.