Study On The Change Law Of Serum 2,3-DPG、VEGF Between Three Types Of Lung Distension

Objective: This subject through combining modern medicine and traditional Chinese medicine syndrome differentiation and therapeutic features,In clinical common lung distension three syndrome types edema syndrome due to yang deficiency,syndrome of insufficiency of lung and kidney qi, lung and phlegm-heat obstructing lung syndrome in patients with serum 2, 3- DPG, VEGF as the main test indicators,supplemented by TCM symptom scores and clinically relevant inspection items, to study the the change rule and correlations of serum 2, 3- DPG, VEGF levels in lung distension,and further study of its internal mechanism,as to provide scientific basis for clinical diagnosis and treatment of lung distension disease.Method: This subject design scheme using random parallel control observation,through the method of clinical epidemiological investigation, according to the cases included in standard cases collected a total of 103 cases, among them 40 patients with edema syndrome due to yang deficiency, 34 patients with lung and kidney deficiency syndrome and 30 patients with phlegm-heat obstructing lung syndrome. According to the lung distension clinical main symptom scores, the Left ventricular ejection fraction,pulmonary artery pressure in heart color ultrasound, blood routine, arterial blood gas analysis, lung function(FVC1 % pred, FVC % pred, FEV1 / FVC %) and lung function classification, ELISA assay to detect serum 2, 3- DPG, VEGF level.Observe the changing rule of the clinical symptoms and related laboratory index in lung distension three syndrome types, evaluation the influence and correlation of serum 2, 3- DPG and VEGF and other clinical observation indexes in the lung distension three syndrome types.Result:1. 2,3-DPG and VEGF in lung expansion three types by comparing the mean level are: Yang deficiency water pan group > lung and kidney deficiency group >phlegm heat obstructing lung group;2,3-DPG and VEGF were statistically significantbetween the two groups of Yang deficiency water pan group and phlegm heat obstructing lung group(P < 0.05).2. The cough score in three types are: Yang deficiency water pan group > phlegm heat obstructing Lung Group > lung and kidney deficiency group; Sputum score mean level: phlegm heat obstructing lung group > Yang deficiency water pan group > lung and kidney deficiency group; The cough and expectoration score of lung and kidney deficiency group were significant compared with Yang deficiency water pan group and phlegm heat obstructing lung group(P < 0.05).3. The asthma and cyanosis score in three types are: Yang deficiency water pan group > lung and kidney deficiency group > phlegm heat obstructing lung group;The asthma and cyanosis score of phlegm heat obstructing lung group were statistically significant compared with Yang deficiency water pan group and lung and kidney deficiency group;4. The BNP, PAP mean level in three types are: Yang deficiency water pan group >lung and kidney deficiency group > phlegm heat obstructing lung group;The LVEF mean level in three types are: phlegm heat obstructing lung group > lung and kidney deficiency group > Yang deficiency water pan group; The LVEF mean level of Yang deficiency water pan group was statistically significant compared with phlegm heat obstructing lung group and lung and kidney deficiency group.5. The WBC, NEUT% mean level in three types are: phlegm heat obstructing lung group > Yang deficiency water pan group > lung and kidney deficiency group; The NEUT% of lung and kidney deficiency group was statistically significant with phlegm heat obstructing lung group and Yang deficiency water pan group.6. The 2,3-DPG and VEGF between the cough scores and VEGF of Yang deficiency water pan group and phlegm heat obstructing lung group showed a significant positively correlation.8. The Hb and HCT level of lung and kidney deficiency group showed a significant negative correlation.9. Between SO2 and VEGF level of phlegm heat obstructing lung group showed asignificant negative correlation(P<0.05). As the while 2,3-DPG and VEGF showed a significant positively correlation(P<0.05).Between WBC and LVEF level of phlegm heat obstructing lung group showed a significant negative correlation(P<0.05).Conclusion : 1. The serum levels of 2,3-DPG and VEGF in the patients with pulmonary inflation can reflect the severity of the disease, and the level of the patient is increased. Lung inflation common syndrome in Yang deficiency of water pan card carrying oxygen capacity is decreased.2. Edema syndrome due to Yang deficiency cough is caused by phlegm, sputum of lung and kidney qi deficiency cough and expectoration less.3. Yang water pan card, a higher degree of cyanosis, asthma, phlegm heat obstructing lung syndrome of asthma, mild cyanosis.4. With the increase of BNP and the decrease of LVEF, it becomes the trend of the deficiency of the lung, and is the key indication of the syndrome of Yang deficiency.5. Phlegm heat obstructing lung infection heavier, lighter infection of lung and kidney qi deficiency.6. Lung and kidney qi deficiency with increased of VEGF, reduced hemoglobin oxygen carrying capacity.7. Lung and kidney qi deficiency with lower hemoglobin and hematocrit decreased,increased VEGF.8. With the increase of VEGF, the oxygen saturation decreased gradually with the increase of the infection and the significant dysfunction of the center of gravity.