Study On Regulations Of TCM Therapy Based On Differentiation Of Symptoms In Middle And Aged Women With Sjogren’s Syndrome

Objective:Through the related literature collation and analysis of Traditional Chinese Medicine and Western medicine treatment of Sjogren’s syndrome in the recent years and based on the collection and statistical analysis of clinical cases of the disease, Then summarize the rules of syndrome differentiation and the laws of medicine application, in order to provide some help to Scientific research and clinical treatment of this disease.Method:Retrospective study was used in this study,140 cases of middle and aged women with Sjogren’s syndrome were chosed, Their age, symptoms, tongue and pulse, pattern of syndrome, drug information were input into the Microsoft office Excel 2010, using SPSS Statistics IBM 22 statistical software for statistical analysis, and using frequency analysis and cluster analysis method, in order to preliminary summary the rules of syndrome differentiation and the laws of medicine application in the middle and aged women with Sjogren’s syndrome.Results:1.Syndrome regularity:In the 140 patients, the most frequently syndrome types for tongue proper is red tongue,which account for 60.71%;For tongue coating is little coating, account for 26.43%;For pulse condition is thready pulse related pulse(such as thready pulse,thready slippery pulse,thready deep pulse, thready relaxed pulse thready slippery pulse etc.), which totally account for 88.5%; For other symptoms, the more common symptoms (frequency of ≥25%) are dry mouth,dry eyes or foreign body sensation joint pain,dental caries,dyssomnia, fatigue,loss of appetite, dry mouth,and the most common of these symptoms is dry mouth, which account for 97.14%.The most common syndromes are internal heat due to Yin deficiency type,account for 22.86%,then it’s deficiency of both Qi and Yin, liver-kidney Yin deficiency,Yin deficiency and dampness,Yin deficiency and blood stasis,Yin deficiency and damp-heat successively.Internal heat due to Yin deficiency type characteristics of dry mouth,dry eyes or foreign body sensation,red tongue with scant liquid,or fissured tongue,less moss or no fur, thready pulse or thready rapid pulse,sometimes have fever,dizziness,dyssomnia,the more typical symptom is fever;Deficiency of both Qi and Yin type account for 20.71%,the more typical symptoms are clear sense of fatigue,spontaneous sweating,dry stool, red tongue and less fluid,less moss or thin white coating, thready pulse,loss of appetite, dyssomnia; Liver-kidney Yin deficiency type account for 18.57%,the more typical symptoms are dry mouth,dry eyes or foreign body sensation,blurred vision, dental caries,red tongue and less fluid,less moss,crack tongue, pulse string, restless sleep last night, joint pain, dry stool; Yin deficiency and dampness type account for 17.14%,the more typical symptoms are white greasy coating and tooth mark tongue; Yin deficiency and blood stasis account for 14.29%,the symptoms which different from other types are dark red tongue, joint pain obviously, skin purpura, parotid gland swelling, Raynaud’s phenomenon; Yin deficiency and damp-heat type account for only 6.43%, the typical symptoms are yellow greasy moss, loose stools and loss of appetite.2. Using drugs regularity:For all the 140 patients, according to their usage, the top 10 drugs are radix Ophiopogonis 72.14%, radix rehmanniae 69.29%, radix adenophorae 66.43%, licorice 62.14%, glehnia littoralis 57.14%, dendrobium 52.14%, fructus lycii 42.86%, white peony root 37.86%, Salvia 37.14%, tangerine peel 32.86%, drug discovery classify frequently used drug classes were 35.44% yin tonic, antipyretic 18.84%,12.05% qi medicine, blood medicine 7.37%, 5.73% blood circulation drugs. Classification of drugs according to efficacy, drugs which have the high frequency of use are nourishing yin drugs(35.44%), heat-clearing drugs(18.84%), tonifying Qi drugs(12.05%), nourishing blood drugs(7.37%), blood activating and stasis eliminating drugs(5.73%). Internal heat due to Yin deficiency type should treat by Nourishing Yin, clearing heat and cooling blood drugs; Deficiency of both Qi and Yin type should treat by nourishing yin, strengthening spleen and supplementing Qi drugs; Lliver-kidney Yin deficiency type should treat by tonifying the liver and kidney, nourishing Yin and generating body fluid, strengthening spleen and supplementing Qi, suppress heat and nourish the blood and promoting blood circulation drugs; Yin deficiency and dampness type should treat by drying dampness and strengthening the spleen and nourishing Yin drugs; Yin deficiency and blood stasis type should treat by Nourishing Yin, activating blood circulation and eliminating stasis drugs; Yin deficiency and damp-heat type should treat by strengthening spleen and replenishing Qi, cleaning heat and drying humidity, promoting blood flow and nourishing Yin drugs.Conclusion:1.The main symptoms for Sjogren’s syndrome in middle and aged women is dry mouth,dry eyes or foreign body sensation joint pain,dental caries,restless sleep,fatigue, loss of appetite, red tongue, little coating or no coating and thready pulse. And it should be treated by Nourishing Yin and moistening dryness method. This disease is divided into six types,they are internal heat due to Yin deficiency, deficiency of both Qi and Yin, liver-kidney Yin deficiency, Yin deficiency and dampness, Yin deficiency and blood stasis, Yin deficiency and damp-heat successively.2.Internal heat due to Yin deficiency type characteristics of dry skin, red tongue with scant liquid,or fissured tongue, sometimes have fever, dizziness, night sleep uneasy. We should treat by Nourishing Yin, clearing heat and cooling blood method, the prescription is shaoyao-gancao decoction combine one pentrating decoction without szechwan chinaberry fruit;The main characteristics of deficiency of both Qi and Yin type is clear sense of fatigue,spontaneous perspiration, treatment with nourishing yin, strengthening spleen and supplementing Qi method,the prescription is Yiwei decoction combine Buzhongyiqi decoction;The main characteristics of liver-kidney Yin deficiency type is blurred vision, dental caries, crack tongue, thin string pulse, the cure is tonifying the liver and kidney, nourishing Yin and generating body fluid, strengthening spleen and supplementing Qi, suppress heat and nourish the blood and promoting blood circulation, the prescription is Yiwei decoction combine the lycii and chrysanthemi and rehmanniae bolus and erzhi pills; The main characteristics of Yin deficiency and dampness type is red tongue or pale tongue,white greasy tongue coating or tooth marked tongue, loss of appetite,the cure is drying dampness and strengthening the spleen and nourishing Yin, the prescription is Yiwei decoction combine shenling baizhu powder;The main characteristics of Yin deficiency and blood stasis type is joint pain, skin purpura, swelling of parotid gland, Raynaud’s phenomenon, dental caries, dark-red tongue, we can treat by nourishing Yin, activating blood circulation and eliminating stasis method, the prescription is Shashen Maidong Decoction combine Taohong Siwu decoction;The main characteristics of Yin deficiency and damp-heat type is lack of appetite, red tongue or fissured tongue, yellow greasy moss, thready and rapid pulse, loose stools etc, the cure is strengthening spleen and replenishing Qi, cleaning heat and drying humidity, promoting blood flow and nourishing Yin, the prescription is mysterious four pill combine four gentlemen decoction and Yiwei decoction.