Clinical Observation On Treating Nonerosive Reflux Disease With The Method Of Qingrehewei

Objective:Observing the improvement of the Nonerosive Reflux Disease clinical symptoms by curing the Nonerosive Reflux Disease with the method of Qingrehewei and doing a randomized controlled with taking omeprazole.It can be used to evaluate the effective of the method of Qingrehewei objectively.And it can also be used to promote the clinical application of this method.Methods:40 cases with NERD are divided into two groups at radom.The treatment group is given precompounded prescription order of the method of Qingrehewei,and the contorl group treated with taking omeprazole(20mg bid). Both courses of treatment for this two groups are 8 weeks.This work evaluates the clinical effects objectively of the method of Qingrehewei by calculating symptom score and the score of Reflux Disease Questionnaire before and after treatment and observing the side-effect.Results:l.The effective of Traditional Chinese Medicine symdrome:There are 20 cases in the treatment group,and after treatment,5 cases are cured,12 cases are markedly effective,1 case is effective,2 cases are ineffective.The total effective rate is 90%,and markedly effective rate is 60%.There are 20 cases in the control group,and after treatment,0 case is cured,4 cases are markedly effective,8 cases are effective,8 cases are ineffective.The total effective rate is 60%,and markedly effective rate is 20%.Comparing the effect of improving clinical symptoms with two groups, the treatment group is better than control group (P<0.05),and comparing the markedly effective rate, the treatment group is significantly better than control group (P<0.01)2.The change of clinical symptom score:After treatment,there is a decline in the treatment group(P<0.05、P<0.01).In the control group, symptom score like acid regurgitation, heartburn, belching, bitter mouth, dry mouth and pharyngeal foreign body sensation all decreased after treatment (P< 0.05、P< 0.01),and epigastric fullness, two rib fullness, chest pain, irritability still existed (P> 0.05).Comparing individual clinical symptom scores of two groups before and after treatment, the result of the treatment group do better than the control group in symptoms like regurgitation, heartburn, epigastric fullness swell (P< 0.01、P< 0.05). No significant difference showed between symptom scores of two groups in belching, two rib fullness, mouth bitterness and mouth dry, chest tightness, chest pain, pharyngeal foreign body sensation irritability (P> 0.05).3. Comparison of the total symptom score:After treatment,both of the two groups were apparently decreased,the treatment group can do more than the control group significantly (P<0.01).4.The change of the Reflux Disease Questionnaire score:Comparing the Reflux Disease Questionnaire score of the treatment group,after treatment,there is a obvious improvement of its frequency and severity(P<0.01). In the control group,after treatment,there is also a improvement of the frequency and severity (P<0.01、P<0.05).Comparing two groups after treatment,the treatment group can do more than the other one in the part of the frequency and severity of acid regurgitation, the frequency and severity of regtlrgitation,and the severity of heartburn (P<0.05),but there is no obvious difference in the part of the frequency and severity of non cardiac pain and the frequency of heartburn (P> 0.05).5. Untoward effect:There is not any untoward effect during the therapeutic process.Conclusion:Curing the Nonerosive Reflux Disease with the method of Qingrehewei can significantly improve the clinical symptoms. No any untoward effect during the therapeutic process means that it is safe and effective to cure the Nonerosive Reflux Disease with the method of Qingrehewei.