The Impact Study Of ABO Hemolytic Disease Of Newborn On Organ Function At Different Gestational Ages

Objective:Conducting a retrospective study of ABO hemolytic disease of newborn at different gestational ages (ABO-HDN) 196 cases by observing the indexes of blood biochemistry, blood coagulation, and blood glucose during hospitalization, then evaluate the variation of these indexes which may affect on organ function of neonate.Methods:Selecting inpatient newborns in pediatrics ward from February,2013 to April,2016 at the second affiliated hospital of Kunming Medical University with the final diagnosis of ABO hemolytic disease 196 cases, divided it into three groups including Small Gestational Age Group (SGA Group, n=29), Appropriate Gestational Age Group (AGA Group, n=132), and Large Gestational Age Group (LGA Group, n=35); And randomly choosing hospitalized of full term infants in the recovery stage of diseases with no jaundice as a Control Group (n=75). All the observed groups were immediately checked for blood biochemistry, blood coagulation, blood glucose’s index, and then used statistics to analyze the variation of these indexes.Results:1. Hepatic Function(1) The serum level of ALT for SGA, AGA, LGA and Control Group were (19.54±3.88 U/L), (20.29±3.70 U/L), (16.54±3.50 U/L) and (13.45±1.48 U/L), respectively; SGA and AGA Group’s ALT level were higher than Control Group’s, there’re statistical significance between these groups (P<0.05); the rest comparisons between two-two groups have no statistical differences (P>0.05).(2) SGA, AGA, LGA and Control Group’s AST serum level were (63.24±10.68 U/L), (59.02±3.53 U/L), (53.79±8.12 U/L), and (41.36±3.88 U/L), respectively; these three research groups’ AST values were higher than that of Control Group, there’re statistical significance differences between these groups (P<0.05); the rests’ comparisons between each observed groups have no statistical differences (P>0.05).2. Renal FunctionThe serum level of BUN and UREA indexes were (3.20 ± 0.85 mmol/1; 56.20 ± 7.76 μ mol/1), (3.43 ± 0.33 mmol/1; 55.89±6.07 μ mol/1), (3.04 ± 0.65 mmol/1; 50.75 ± 7.69 μ mol/1), (2.94 ± 0.32 mmol/1; 51.58 ± 5.33 μ mol/ 1), respectively; and the comparisons of BUN and UREA levels between each group have no statistically significant differences (P>0.05).3. Cardiac EnzymesSGA, AGA, LGA and Control Group’s CK-MB level were (53.48±11.59 U/ L), (42.83±3.96 U/L), (39.08±6.67 U/L), (28.69±4.38 U/L), respectively; these three observed group’s CK-MB values were higher than Control Group’s, there’re statistical significance (P<0.05); and for the rests’ comparisons between observed groups have no statistical differences (P>0.05).4. Blood Coagulation Function(1) SGA, AGA, LGA and Control Group’s PT values were (18.86 ± 2.85s), (16.45 ± 1.73s), (17.14± 2.65s), and (15.60±1.49s), respectively; SGA and LGA Group’s PT level were higher than that of Control Group, there’re statistical significance differences between these groups (P<0.05); the rest groups’ comparisons between each group have no statistical difference (P>0.05).(2) SGA, AGA, LGA and Control Group’s APTT level were (54.70±7.62s), (42.35±3.18s), (42.13±4.73s), (38.56±2.02s), respectively; these three observed group’s APTT values were higher than Control Group’s, there’re statistical significance (P<0.05); SGA’s APTT level was higher than that of AGA and LGA group, there’re statistical differences (P<0.05); the rest groups’ comparisons between each group have no statistically significant differences (P>0.05).(3) SGA, AGA, LGA and Control Group’s FIB indexes were (2.80±0.35 g/1), (2.85±0.21 g/1), (3.01±0.39 g/1), (2.87±0.20 g/1), respectively; and the comparisons in between two-two of each group have no statistical differences (P>0.05).(4) SGA, AGA, LGA and Control Group’s TT values were (18.07±3.80s), (16.73±2.69s), (16.47±1.26s), and (15.89±2.57s), respectively; SGA group’s TT level were higher than Control Group’s, there’re statistical significance (P<0.05); the rest groups’ comparisons between each group have no statistically significance difference (P>0.05).5. Blood GlucoseThe incidence rates of hypoglycemia in each observed group (SGA,AGA, LGA Group) were 3.44%,3.78%,0.00%, respectively; among all of observed groups, the hypoglycemia’s incidence rate was 3.06%. In addition, the comparisons of incidence rates between each observed group have no statistically significance differences (P<0.05)Conclusions:1. ABO hemolytic disease of newborns may cause hepatic function, renal function, cardiac enzymes, blood coagulation, and glucose metabolism’s abnormal changes.2. The impact of ABO hemolytic disease of newborn on organ function has no significant correlation with different gestational ages.