Yiqiyangyinghuoxue Ameliorate Proteinuria Of Primary Glomerulopathy

ObjectiveThe purpose of this research is to explore the curative effect of yiqiyangyinhuoxue therapy on people who suffer from primary glomerulopathy with proteinuria. A retrospective study is performed in this research to observe the improvement of proteinuria after treatment with Yiqiyangyinhuoxue therapy. Hope to provide a new effective therapy for renal proteinuria for clinical.Method59 patients, suffered from primary glomerulopathy with proteinuria between 2.0～3.5 mg/24h, is selected from Shenzhen Hospital of traditional Chinese medicine into this study. All patients were divided into two groups, case group(30 cases with Yiqiyangyinhuoxue therapy combined with ACEI therapy) and control group (29 cases with ACEI therapy).24h urinary protein, TCM symptom scores and some other indicators are observed before and after treatment of each group. SPSS statistical software is used to perform data analysis.Results1. efficacy of proteinuria:24h urine protein was both significantly decreased (P＜0.05) 6 months after treatment with Yiqiyangyinhuoxue combined with ACEI and ACEI alone. The case group decreased proteinuria much more than the control group (P＜0.05). According to the Curative Evaluation Criteria in proteinuria, Among patients observed in the case group,3 cases were clinical remission,18 cases were significantly improved,8 cases were mildly improved,1 cases was not improvement, and the total efficiency index is 96.7%. Among patients observed in the control group,1 cases was clinical remission,12 cases were significantly improved,9 cases were mildly improved,7 cases were not improvement, and the total efficiency index is 75.9%.2. TCM symptoms efficacy:both two groups could effectively reduce the total score of TCM symptoms, clinical symptoms of patients in case group improved more compared with control group (P＜0.05). According to TCM syndromes evaluation criteria, there were 0 case with clinical cured,3 cases with significantly improvement,18 cases with mildly improvement,9 cases with no improvement, and the total efficiency index is 70% in case group, for the control group, there were 0 cases with clinical cured,1 cases with markedly improvement,12 cases with mildly improvement,16 cases with no improvement, and the total efficiency is 44.8%. the difference between the two groups was statistically significant.3. The laboratory indicators:the serum creatinine (Scr) and the glomerular filtration rate (eGFR) were not significantly changed in both the case group and the control group after treatment. The serum albumin (ALB) and high-density cholesterol (HDL-C) were elevated (P＜0.05), and the triglycerides (TG) was reduced(P＜0.05) in the case group. For blood urea nitrogen (BUN), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), low density lipoprotein (LDL-C), there were no significant improvement in both groups. Conclusion"Qi-yin deficiency and blood stasis" is the important pathogenesis of primary glomerular disease proteinuria. Yiqiyangyinhuoxuefang can reduce proteinuria and improve the clinical symptom of patient with primary glomerular disease proteinuria for the type "Qi-yin deficiency and blood stasis", but perform no effect on renal function.