The Clinical And Experimental Study Of The Bu Shen Qiang Du Method On Treating Of The Patients With Numbness Of CSR After Surgery

ObjectiveTo observe the effects and possible mechanism of the Bu Shen Qiang Du method on damaged nerve roots of cervical by the animal experiment and Clinical research. Provide clear and effective treatment method and objective clinical basis for the clinical treatment of CSR postoperative numbness. Provide a theoretical basis for the clinical accurate use, law, parties, drugs.Methods1. Experimental study1.1 The nerve root type cervical spondylosis animal model establishment and intervention:through the canal in line modeling method, nerve root type cervical spondylosis mouse model was established, the modeling and randomly assigned to two groups. The control group was given normal saline, the experimental group give a bi party concentrated Chinese medicine orally administered for 15 days.1.2 Methods the animal model of cervical spondylosis of nerve root type 2 Evaluation:electrophysiological measurements:record and calculate the operation side potential amplitude (C6AmP), the difference of latency (E’-C6Lat) and potential conduction velocity (Mcv). Pathological observation: To observe nerve morphology by HE staining and scanning electron microscope.2. Clinical researchUsing visual analog scale (visual analogue scales;VAS), cotton quantitative sensory testing method and Tian signed 20 subscales assess numb degree and curative effect to improve the situation. Results1. Electrophysiological detection:comparison of somatosensory evoked potential (Mcv) conduction velocity, amplitude and latency (C6AmP) value (E’-C6Lat) results. After the end of treatment, the difference between the two groups had significant difference (P＜0.01);comparison of two groups, the control group before treatment and after treatment comparison showed no statistical significance (P＞0.05), neural electrophysiological studies showed no significant recovery or not restored to normal levels. The experimental group before and after the treatment results were statistically significant (P＜0.01), electrophysiological results in significant recovery. Pathological observation:, the severity of nerve tissue damage was severe in control group.2. The (visual analogue scales (VAS) and cotton swabs of quantitative sensory testing method, the treatment group and the control group, the score of numbness results in 6 and 12 weeks the difference was statistically significant (P＜0.05), the two groups at the end of follow-up, through Tian 20 component table to evaluate the curative effect and treatment group, the excellent and good rate was 85%, control group, the excellent and good rate was 50%, the difference of the efficacy of the two groups is significant (P ＜0.05), the treatment group curative effect surpasses the control group.Conclusion1. Through the observation on neural physiological detection and morphology of electricity, the Bu Shen Qiang Du method can improve neural function of The CSR rat model which was established by spinal canal in line method. It can obviously restore neural electrophysiological results., and promote the nerve morphology and nerve function recovery of the damaged nerves2. The Bu Shen Qiang Du method can significantly improve neural function、 alleviate the symptoms of numbness、relieve the clinical symptoms, and improve the quality of life, it is worthy of promotion and application.