Effect Of FRAX^? On Evaluating The Change Of Bone Mineral Density In Postmenopausal Women

Objective This study aims to investigate the effect of WHO Fracture Risk Assessment Tool (FRAX(?)) on reflecting the change of bone mineral density in postmenopausal women, and to evaluate the applicability of the FRAX(?) tool to discriminate high risk osteoporosis populations.Methods 166 postmenopausal women were recruited including outpatients, hospitalized patients and people who underwent health assessment in the First Affiliated Hospital of Guangxi Medical University. Bone mineral density was measured by dual energy x-ray absorptiometry. All risk factors were collected from subjects requested in the FRAX(?) assessment. Each individual 10-year probability of major fracture and hip fracture were calculated by the FRAX(?) algorithms of Chinese model (with and without BMD). The statistical analysis was performed with a SPSS software.Results The patients with abnormal bone mass (osteopenia or osteoporosis) had elder age (P<0.01), light weight (P<0.01), lower BMI (P<0.05), more reduction in height (P<0.01),longer menopause duration (P<0.01) compared with the normal group. Except for history of fragility of fracture, other clinical risk factors were not significant between the two groups. The FRAX(?) predictions of fracture (with or without BMD) and T values of femoral neck appeared in an obvious negative correlation (P<0.01), and there was a positive correlation between the FRAX(?) predictions of fracture with and without BMD (P<0.01). Along with the increase of age or osteoporosis-risk by IOF one-minute osteoporosis risk test or OSTA, incidences of osteopenia and osteoporosis were roughly on the rise, and higher 10-year probabilities of osteoporotic fracture were observed (P< 0.01). Receiver operating characteristic curve analysis showed that PMOF (Area under the curve:0.705, P<0.001), PHF (Area under the curve:0.743, P<0.001) could identify abnormal bone mass density in postmenopausal women.Conclusion The application of the FRAX(?) tool can not only give an opportunity to determine structural-functional changes of bone, but help to recognize high risk osteoporosis populations in postmenopausal women effectively as a primary screen tool.