Clinical Research On Treating Intrahepatic Cholestatic Jaundice With The Method Of Liangxuetuihuang

Objective:To evaluate the clinical efficacy of the method of liangxuetuihuang on treatment of intrahepatic cholestatic jaundice.Methods:40 patients met the diagnosis of intrahepatic cholestatic jaundice, according to the principle of random distribution, were divided into two groups averagely:the treatment group and control group, each group contained 20 cases. Control group:oral administration of ursodeoxycholic acid capsules, each time 1 grain (250mg/grain) three times a day, the total course of 4 weeks. Treatment group:on the basis of the treatment of control group and aid the oral administration of Liangxuetuihuang decoction for 4 weeks, twice a day. Two groups of patients in the anti-viral therapy continue the original program. Recorded patients’serum liver function and traditional Chinese medicine (TCM) syndrome scores for every two weeks. According the comparing analysis of two groups, we can evaluate effect of removing pathogenic heat from the blood and treating jaundice method.Results:Intrahepatic cholestatic jaundice may be named as "yurehuang" according to its pathogenesis. Stasis Heart is the key pathogenesis of intrahepatic cholestasis jaundice.The method of liangxuetuihuang is the main treatment of intrahepatic cholestasis jaundice. ②From the analysis of evaluation of TCM syndrome effect, the overall efficiency of the treatment group was 80%, the overall efficiency of the control group was 60%, so the clinical efficacy between the two groups has a significant difference (p<0.05). ③In terms of improvement of serum bilirubin, TBiL and DBiL’s level of treatment group (compared before and after four weeks’ treatment) were significantly decreased after treatment, and has a significant difference (P<0.001) compared with pre-treatment. TBil value before and after treatment, the difference compared with the control group, the difference was significant (p<0.05). Compared the the treatment group and the control group,TBiL’s the integral value of before and after treatment has a significant difference (p<0.05). ④In the inpact of improving GGT, ALP, the level of GGT, ALP after treatment was significantly lower than before treatment (P<0.001) both the treatment group and the control group. But after two weeks’treatment,the control group has little improvement of liver enzymes indexes, while the treatment group has a significant improvement (p<0.001).Conclusion:Both the treatment group and control group had a good effect in reducing the level of serum bilirubin and ALT, AST, GGT, ALP, and found no side effects produced during treatment. The treatment group compared with control group, could reduce the level of serum bilirubin and improve liver function more significantly, and have a better therapeutic effect for the ease of TCM clinical syndrome.