The Study Of Cerebral Microbleeds In Patients With Hypertension Using Enhanced T2 Star Weighted Angiography

Objective: 1. To explore the ESWAN sequence in the diagnosis of cerebral microbleeds in patients with hypertension is better than the other conventional MRI sequence or not. 2. To explore the spatial distribution of CMBs in patients with hypertension. 3. Measuring the CPV of the different parts of the CMBs in patients with hypertension and analyze the influencing factors.Methods: Analysis images of 63 patients with hypertension and CMBs in our hospital from April to December in 2015 who came to our department, 40 males and 23 females, age 45 to 86 years old, mean age 65.16±10.85 years old, all the patients underwent conventional MRI scan and ESWAN sequence scan. Observe the number of CMBs in ESWAN sequence and conventional sequence in patients with hypertension, explore the ESWAN sequence in the diagnosis of cerebral microbleeds in patients with hypertension is better than the other conventional MRI sequence or not, differences were considered statistically significant when P<0.05. Compare the numbers of CMBs in different areas to explore the spatial distribution of CMBs in patients with hypertension. Measuring the CPV of the different parts of the CMBs in patients with hypertension, use Spearmanrank correlation analyze the influencing factors such as gender, age and duration of hypertension, differences were considered statistically significant when P<0.05.Results:1. We were totally found 257 CMBs lesions in the 63 patients with EH by ESWAN sequence, 41 CMBs lesions by generic MRI sequence, the ESWAN sequence was positive than the generic MRI sequence in diagnosing CMBs lesions. 2. The thalamus/basal ganglia region has the highest prevalence of CMBs lesions, followed by cortical- subcortical region, the last was infratentorial region. 3. The maximum CPV was-1.45 rad, the minimum CPV was-0.52 rad, the mean CPV was-0.99 ± 0.28 rad. There was significant difference among the mean CPVs in different region(P<0.05); the mean CPVs of CMBs groups was lower than red nucleus and substantia nigra in healthy groups, there was significant difference among the two groups(P<0.05); For mean CPVs of CMBs in cortical- subcortical region, there was significant difference in different age, duration of hypertension and hypertension risk stratification groups(P<0.05), and negatively correlated; For mean CPVs of CMBs in thalamus/basal ganglia region, there was significant difference in different age, duration of hypertension groups(P<0.05), and negatively correlated; For mean CPVs in infratentorial region, there was no significant difference in different groups(P> 0.05), and no significant correlation.Conclusion: 1. The ESWAN sequence was positive than the generic MRI sequence in diagnosing CMBs lesions. 2. The descending order of the morbidity of CMBs is thalamus/basal ganglia region,cortical- subcortical region and infratentorial region. 3. The CPVs of the CMBs in thalamus/basal ganglia region and cortical- subcortical region with different age, hypertension duration, risk stratification has certain rules, measurement of CPVs of CMBs lesions is helpful for detecting the iron content in the CMBs lesion.