The Value Of Direct Renin Concentration(DRC)in Diagnosis Of Primary Aldosteronism

Primary aldosteronism(PA) is one of the most common causes of secondary hypertension. plasma aldosterone concentration(PAC) / plasma renin activity(PRA) ratio is widely used in clinical practice. However, PRA reflects the level of plasma renin indirectly. In recent years, direct renin concentration(DRC) has been measured by automatic chemiluminescence immunoassay,which is more stable, convenient and with less confounding factors than conventional renin activity. This review briefly introduces methods of examining PRA, DRC and PAC, and compares the value of PAC/DRC ratio with PAC/PRA ratio in PA detection.