| Background and Objective:Urothelial carcinoma of the urinary bladder is one of the most common in ourdepartment of urology clinical tumor, is a direct threat to the survival of patients withthe disease. At present, the main means of follow-up monitoring preoperative diagnosis and postoperative is cystoscopy and urine cytology. The gold standard for the diagnosis of bladder tumor of the former, but for invasive examination, and the price is expensive, so that patients feel unwell. The latter is a non-invasive examination, but the sensitivity in diagnosis of bladder cancer is low. In recent years,with the development of molecular biology technology, the emergence of some new methods in the diagnosis of bladder cancer, where BTA stat is the recent researches on bladder tumor marker. In this study, through the evaluation of BTA stat and urinary cytology for detection sensitivity and specificity, compared to two in the diagnosis of bladder tumor value.Methods:2014 January to 2014 December, 100 patients with bladder tumor were collected in General Hospital Affiliated to Tianjin Medical University, including 14 patients because of various reasons, has not obtained the pathology results, therefore, excluded.Ultimately 86 patients were included in the study and statistical analysis of complete.Bladder tumor were 1 BTA urine stat and urine cytology in 3 before operation, treated with operation(transurethral resection of bladder tumor resection or cystectomy) after acquiring the pathological results, according to the pathological results to evaluatetwo methods for the detection of sensitivity and specificity, and compared both in thediagnosis of bladder tumor the value of.Results:The patients were divided into two groups, one group as the case group(pathologic diagnosis), a total of 56 cases; another group of non cases(pathological diagnosis of negative), a total of 30 cases of urinary BTAstat; the sensitivity of diagnosis of bladder tumor were measured: 71%: 63%; the sensitivity, specificity of urine cytologyin diagnosis of bladder cancer: 55%, specificity: 90%. The bladder tumor patientsaccording to thepathological results of grading and staging, the sensitivity of staturinary BTA examination of the bladder tumor patients G1 grade: 64%, the sensitivity of G2 grade in patients with are: 72%, the sensitivity of G3 grade patients: 85%. Thesensitivity of stat staging patients with urinary BTA test on bladder cancer Ta: 62%,sensitivity in patients with stage T1: 77%, sensitivity in patients with stage = T2: 86%.According to the bladder neoplasm infiltration sensitivity determination of stat urinary BTA test in Tis-T1 patients: 58%, the sensitivity of T2-T4 patients was 88%. The sensitivity of cytology for bladder tumor grading of G1 patients was 44%, the sensitivity of G2: classification of patients: 56%, the sensitivity of G3 grade patients: 77%. Staging patients with a sensitivity of cytology for bladder cancer Ta: 45%,sensitivity in patients with stage T1: 62%, sensitivity in patients with stage = T2: 71%.According to the bladder neoplasm infiltration sensitivity determination of stat urinary BTA test in Tis-T1 patients: 42%, the sensitivity of T2-T4 patients was 72%.Conclusions:1. The accuracy of secondary urinary BTAstat detection in diagnosis of bladder cancer,can be as an adjunct to cystoscopy.2. The sensitivity of urinary BTAstat detection in diagnosis of bladder cancer is higher than that of urine cytology, but the specificity was significantly lower than that of urinecytology for detection, so the two can not be replaced each other, more alone cannot be used to diagnosis of bladder tumor.3. By drawing ROC curve can be seen the diagnosis effect of urine BTAstat and urine cytology showed no difference. The combined application of urine BTAstat and urine cytology showed no significant difference between the effect of each individual examination and diagnosis.4. Grading, sensitivity and urine bladder tumors BTA stat detection and urine cytology in diagnosis of bladder cancer staging is closely related to the sensitivity of diagnosis of bladder tumor, two were with the grading, staging of bladder tumor increased, but statwas significantly higher than that of urine BTA detection of urinary cells examination.Two examination in diagnosis of invasive(T2-T4) sensitivity of bladder cancer was higher than thatof superficial bladder cancer(Tis-T1), but the sensitivity of stat is higher than that of urine BTA detection of urine cytology.5. Because of the sensitivity of urinary BTAstat detection in diagnosis of bladder canceris higher than that of urine cytology, so in the detection of urine BTAstat detection is superior to cytology in recurrence of bladder tumor after operation, has become an important supplementary means of cystoscopy.6. Detectionof urinary BTAstat and urinary cytology can not replace cystoscopy was used as the gold standard in diagnosis of bladder cancer, can be as an adjunct tocystoscopy.7. Urinary BTAstat detection steps than urine cytology is simple, only three drops ofpatients with morning urine sample to test plate and can be like the hole, the results are read after 5 minutes.8. BTA stat detection can be affected by many factors, so the diagnosis coincidence rate is low. Any one may damage the urinary tract epithelial integrity and exposed bladderbasement membrane factors can cause false positive.Bladder neoplasms Bladder tumor antigen Urine cytology Cystoscope Transurethral resection of bladder tumor... |
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