Observation Of The Effect Of Early Multiple Puncture And Drainage In The Treatment Of Severe Acute Pancreatitis

Objective: The safety and effectiveness of early puncture and drainage in the treatment of severe acute pancreatitis were evaluated by the clinical symptoms of patients with severe acute pancreatitis, and to observe the changes of clinical symptom relief time, complication rate, incidence rate and laboratory indexes.Methods: A total of 30 patients with severe acute pancreatitis were selected from October2014 to October 2015, and the patients with severe acute pancreatitis were selected according to the inclusion criteria and the exclusion criteria. According to puncture or not, 30 patients were randomly divided into puncture group and control group with 15 cases in each group. To compare the differences in the clinical symptoms, the incidence of complications, the incidence of complications and the recovery of laboratory indexes in the two groups.Results: The puncture group was followed by within the 24 h, and the drainage time was8-13d(average 11d), the drainage time was 2871± 2210 ml. Compared with the control group, the level of C- reactive protein and TNF- α in the puncture group decreased rapidly,the difference was statistically significant. The time of clinical symptom relief, recovery time, hospitalization time and hospitalization expenses of the puncture group were significantly less than those of the control group, the difference was statistically significant.On admission,the plasma TXA2 and PGI2 levels of two groups were no statistically significant difference. The plasma TXA2 level was significantly lower in the puncture group than in the control group at 3 days after treatment, and the difference was statistically significant. At the same time, the plasma PGI2 level in the puncture group was significantly higher than that in the control group, but the difference was not statistically significant. After 7 days of treatment, The plasma PGI2 level was significantly higher in the puncture group than in the control group,the difference was statistically significant.Conclusion: In the early stage, Percutaneous catheter drainage can reduce the level of inflammatory factors in patients with severe acute pancreatitis, and reduce the hospitalization time and reduce the cost of hospitalization. It is an effective method of non-surgical treatment for severe acute pancreatitis, is worth popularizing in clinical application.