An Analysis Of The Relationship Between PLR/NLR And Clinicopathologic Features Of Gastric Cancer And The Effets Of Operation On Them

Objective : To explore the connection between PLR/NLR and the Clinicopathologic feature of gastric cancer. And ulteriorly analyze how the operation affects the variation of both PLR and NLR in gastric cancer patients cured with surgery.Methods:Retrospectively review eligible patients cured with surgery in The First Affiliated Hospital of Chongqing Medical University between Jan 2011 and Jan 2015. Record the clinical data of all the patient in details, including gender, age, Ki67 level, TNM stage, histologic grade, platelet count, neutrophil count, lymphocyte count etc. Calculate the neutrophil-lymphocyte ratio(NLR) and platelte-lymphocyte ratio(PLR) by neutrophil count, lymphocyte count and platelet count. And then explore the variation of PLR/NLR before and after operation, meanwhile, explore the relation between PLR/NLR and the Clinicopathologic feature of gastric cancer before and after operation.Results:For preoperative patient, there is a positive correlation between PLR and tumour size(p=0.03), with the larger tumour higher in PLR, but PLR has no correlation with gender, age, ki67 level, TNM stage and histologic grade(p>0.05), there is a correlation between NLR and gender(p=0.02), with NLR higher in man, but NLR has no correlation with age, ki67 level, tumour size, TNM stage and histologic grade(p>0.05). A week after surgery, both PLR and NLR will rise(p<0.05), but they will decline after 3 months(p<0.05). And six months after the surgery, there will be no significant difference between that of pre and post operation. After surgery, all of the gender, age, tumour size, ki67 level, TNM stage, histologic grade have no significant effects on the change of PLR/NLR(p>0.05). But the surgical methods will affect PLR level, PLR in patients who receive both radical gastrectomy and splenectomy will be higher than patients who just receive radical gastrectomy(p<0.05). As time goes by, PLR in patients who receive both radical gastrectomy and splenectomy will decline. Three months after the surgery, the surgical methods have no significant effects on PLR.Conclusion: For preoperative patient, there is a positive correlation between PLR and tumour size, but PLR has no correlation with gender, age, ki67 level, TNM stage and histologic grade. Men have a higher NLR level than women. However NLR has no correlation with age, ki67 level, tumour size, TNM stage and histologic grade. Operation will lead to a rise of PLR and NLR as time goes by. However, both PLR and NLR level will decline, and about six months later, they will be the same as that before the operation. There is no connection between PLR/NLR and the Clinicopathologic feature after the operation. PLR of patients who receive both radical gastrectomy and splenectomy will be higher than those who only receive radical gastrectomy. However, as time goes by, the PLR level will decline, about three months later, there were be no difference between different surgery metheds.