Based On The Electrospinning Technology To Build Nonenzymatic Sensing Interface Research

In recent years,biosensors have played an important role in various fields,such as medical diagnosis,biotechnology,and the food industry.Specifically,electrochemical methods,which include both enzyme and nonenzyme sensing,have become highly desirable due to their low cost,simplicity,high sensitivity,and real-time detection.However,enzyme sensors are limited since they are not stable,lose activity easily,require complex preparation process,and are costly.The development of nanomaterials offers greater possibility for establishing specific electrode surface with excellent catalytic activity and promotes the progress of electrochemical nonenzymatic sensors.To deeply understand the role of nanomaterials in electrochemical nonenzymatic sensors,we prepared different nanomaterials and use them to design more efficient and ideal nonenzymatic sensor.In this paper,we discuss the development of the sensor and common electrode materials,experimental procedures,analysis of nanomaterial composition,and impact of the detection system on the electrochemical performance of the sensor.The full text content is as follows:1.The nature of a solid catalyst is determined by its chemical composition and atomic structure,which also affect by its morphology,dispersion,grain size,and surface characteristics.To investigate the effect of the catalyst‘s chemical composition on its electrocatalytic performance,the electrospinning technology was used to prepare 1D materials with same texture by controlling experimental parameters.A batch of similar size and microstructured WO3,Co3O4,and Co WO4 nanofibers were prepared and used to study the impact of their composition on their catalytic ability.Electrochemical results show that binary metallic oxides Co WO4 nanofibers for H₂O₂ oxidation show a significant electriccatalytic activity,which is superior to that of WO3 and Co3O4,which suggest that the electrocatalytic ability of catalysts is closely dependent on its chemical composition.2.Our previous work proves the chemical composition of nanomaterials closely impacts their electrochemical activity.Although the mediated reaction of nanomaterials can strengthen their electrocatalytic activity and the catalytic activity of binary metallic oxides is better than that of unitary metallic oxides,a design for a multiple metallic oxide catalyst remains unknown.Thus,we further designed two different binary metallic oxides,one-dimensional Ca Mo O4 and NiMoO₄ with similar morphology and microstructur,using electrospinning technology,and to study their electriccatalytic ability by implementing the nanofibers as the electrode material in a nonenzymatic glucose sensor.The experimental results show that the NiMoO₄ sensor for glucose detection shows good catalytic activity,which is higher than most of the reported Ni O and Co3O4 catalysts.This is attributable to the electron transfer ability and mediated electrochemical reaction of NiMoO₄ nanofibers in electrocatalytic reaction with glucose.The results show that the more active centers participate in catalytic reaction,the higher catalytic activity will be delivered.This work provides a new path for designing excellent catalysts for nonenzymatic glucose sensors.3.Although nanomaterials have high catalytic activity in detection of biological molecules in alkaline conditions,it is unfavorable for real-time analysis of biomolecule.In fact,biological detection in a neutral system is closer to real biological systems.To explore the influence of different detection systems on the electrocatalytic activity of nanomaterials,Ni O and Sn O2 nanotubes with similar microstructure were prepared by electrospinning technology and used in the nonenzymatic sensor.Experimental results show that the catalytic activity of nanomaterial in an alkaline system is higher than in a neutral system.What‘s more,amphoteric oxide Sn O2 in an alkaline system are not stable,but in a neutral system,it was found to be more stable with better catalytic activity,which more closely mimics real biological systems.This provides a new beginning for electrochemical nonenzymatic sensor to find specific nanomaterials with excellent catalytic activity and selectivity.