The Meta Analysis Of The Different Treatments Of Peri-and Post-menopausal Women With Depressive Disorders

Objective: To assess the curative effect of hormone supplementtherapy joint antidepressant drugs, antidepressants or hormone supplementtherapy, in peri-menopausal and post-menopausal patients with depressivedisorder, in order to guide clinical work.Methods: Two reviewers systematic collect relevant literatures bycomprehensive retrieving a number of online database, screen documentsindependent, bring into the randomized controlled trial (RCT) and cohortstudy in both English and Chinese, evaluate the included literatures anddata extraction, using RevMan5.2software to complete the Meta analysis.Results: After screening,19participants were included, among them,10pieces were RCTs, and cohort studies on9, total sample size of2312cases. The Meta analysis shown:1) among the eleven studies, the effectiverate of hormone combination antidepressant group is higher thanantidepressant group（RR1.17，P=0.005）, but the curative ratio has nostatistical difference（sRR1.17，P=0.07).2) in the five studies, the curativeratio (RR1.73，P=0.003） and effective rate （RR1.52，P＜0.00001） of hormone combination antidepressant group are higher than hormonesupplement therapy.3) the antidepressant group has higher effective rate（RR1.37，P=0.003）than hormone therapy.4) the curative ratio （RR2.17，P=0.003） of hormone therapy group is higher than placebo group,but the effective rate has no statistical differences.Conclusion: Although the hormone supplement therapy has sometherapeutic effect for peri-menopausal and post-menopausal depression, itcan not replace the dominance of antidepressants. However, add thehormone replacement therapy to antidepressant according to individualcircumstances can improve the efficacy of antidepressants. Thisimprovement function still need more and larger randomized controlledtrials to verify.