Coronary Risk Factors And Angiographic Characteristics Of Young Women With Coronary Heart Disease

Background As medical technology continues to present male mortality in patients with coronary heart disease decreased, while women, especially young female patients with coronary heart disease moronary is rising, so this study for young women with coronary heart disease risk factors in patients with clinical and angiography characteristics analysis.Objective To investigate the clinical risk factors and angiographic characteristics of young women with coronary heart disease, in order to provide the basis for clinical prevention, diagnosis and treatment.Methods One hundred and seventy-seven women under the age of 50 were selected from July 2012 to September 2014 with coronary heart disease or suspected coronary heart disease in the First Affiliated Hospital of Xinxiang Medical College. They were divided into coronary heart disease group (group A) and coronary artery normal group (group B) according to coronary angiography. According to the clinical features of coronary heart disease group was divided into stable angina, unstable angina and acute myocardial infarction. Comparative analysis was performed between the two groups to study the coronary heart disease risk factors and coronary angiographic features.Results (1) Traditional risk factors:Compared to group B, there were more women with hypertension, menopause, diabetes, obesity (BMI≥28Kg/m2), reduced high-density lipoprotein, A-type personality in group A (P<0.05).The level of estradiol in group A was lower than that in group B(P<0.05). But both groups had similar age, family history of coronary heart disease, LDL, total cholesterol, triglycerides, lipoprotein (a) (P>0.05). (2) New risk factors:Compared with group B, serum levels of total bilirubin, indirect bilirubin were significantly decreased(P<0.05)and plasma fibrinogen significantly increased in group A(P<0.05).But hemoglobin, blood uric acid, HCT. serum Cys-c between the two groups showed no significant difference(P>0.05). (3) Compared with the single branch lesion group, total bilirubin, indirect bilirubin were significantly decreased in the multi vessel disease group, the difference was statistically significant(P<0.05). The plasma fibrinogen level in the unstable angina and acute myocardial infarction group was significantly higher than that in stable angina pectoris, the difference was statistically significant (P<0.05).(4)Logistic regression analysis showed that the independent risk factors of coronary heart disease women under the age of 50 were hypertension (OR=6.302), reduced high-density lipoprotein (OR=3.490), A-type personality (OR=3.237) and high triglycerides (OR=2.338) (P<0.05). (3) Coronary angiography of coronary heart disease group showed single vessel disease in 34 cases (48.57%), of which 28 cases of left anterior descending artery disease (82.35%), double vessel disease in 16 cases (22.86%), three lesions in 20 cases (28.57%).Conclusion 1.High blood pressure, reduced high-density lipoprotein, A-type personality and hypertriglyceridemia are the major risk factors for female patient under the age of 50 with coronary heart disease; Plasma fibrinogen level can reflect state of an illness in young female patients with coronary disease. In particular, it has an important clinical value in early diagnosis of acute coronary syndromes; Low serum bilirubin level may be involved in the pathogenesis and progress of young women with coronary heart disease.2. the coronary artery disease is more common in single-vessel disease, mainly involving the left anterior descending artery.