Effect Of ABO Blood Group On Prognosis Of Primary Non Muscle Invasive Bladder Cancer

Compared with other cancers in urinary system,bladder cancer has the highest disease incidence in China,whose percentage of occurrence is 3.2% in systemic malignant tumor.Depends on a clinical cohort analysis,particularly,95% of bladder cancer is urothelial carcinoma,which shows as a frequently-occurring type.In 1981 the urological association has been established,who have received a report about 5503 cases of bladder cancer from 20 provinces,in which 4462 cases(97.3%)are urothelial tumors and 1041 cases(2.7%)are non-urothelial tumors.In urothelial tumors,transitional cell carcinoma accounts for 92.8%,squamous cell carcinoma and adenocarcinoma accounts for 2.5% and 3.1%,respectively,the rest portion is benign papilloma which accounts for 1.6%.Every year,there are about 386,300 new cases and 150,200 dead cases of patients who had urothelial tumors [1].The first time diagnostic rate of urothelial carcinoma in bladder tumors is more than 90%,but only 75%-85% pathological diagnosis in urothelial carcinoma are Nonmuscle Invasive Bladder Cancer(NMIBC),which includes clinical stage Ta,T1 and Carcinoma In Situ(CIS).Currently,the most commonly used treatment for Nonmuscle Invasive Bladder Cancer(NMIBC)is Transurethral Bladder Resection(TURBT)combined with intravesical chemotherapy.These tumors generally will not lead to the death of patients,but 50%-70% of them will relapse and there is about 10%-20% of them will eventually develop into muscle-invasive bladder urothelial carcinoma(T2-T4 stage),owing to the primary Nonmuscle Invasive Bladder Cancer(NMIBC)is a heterogeneous disease.So an accurate prognosis for each patient is very important.For predicting the prognosis of patients who had primary NMIBC in a more efficient way,I have searched abundant relevant literature and found that the ABO blood group is a potential prognostic factors.What’s more,the ABO blood group has a wide practicability in the overwhelming majority of patients.ABO blood group gene locate on the No.4 belt of the third district in long arm of chromosome 9.In bladder cancer,this region shows a highly variation.The expression of ABO antigens in bladder cancer tissues decrease with an increase of pathological grades.20 years ago,some foreign researchers reported that survival rate of patients with bladder cancer is related to the grade of ABO blood group.But these researches depend on a limited number of samples.ABO blood group will improve current methods for predicting the recurrence and progression of NMIBC and as a support for clinical treatment or pathological diagnosis.Meanwhile,the cheap price and practicable reproducibility of ABO blood group are the necessary factors of an ideal biomarker.Differences in races and geography often lead to a variant in morbidity and mortality of bladder cancer,while the ABO blood group system antigen has a very stable genetic traits,which would not change with the random mutation and hybridization.In China,bladder cancer is the most common malignancy in genitourinary system,to date,there is no substance used as an ideal detector for prognosis.The purpose of this article is trying to verify the relationship between ABO blood group and Nonmuscle Invasive Bladder Cancer(NMIBC)in pathology,recurrence and progression.Objective: ABO blood group is the number of cancer prognostic factors have been established,but its role in bladder urothelial carcinoma is largely unknown.Explore the relationship between ABO blood group and primary non-muscle invasive bladder cancer prognosis.Methods: Review of 2005 January to January 2015 713 cases of primary non muscular layer infiltration of bladder cancer patients and in our hospital underwent transurethral resection of bladder tumor cut surgery and postoperative mitomycin and hydrochloric acid pyridine soft than star intravesical chemotherapy in treatment.Univariate and multivariate competitive regression models for the analysis of disease recurrence and progression.Mean follow-up time was 63.7 months.Results: In the ABO blood group type A patients were 241 cases(46.1%),B type has 66 cases(12.7%)O type 178 cases(34.2%)and AB 36 cases(6.9%).ABO blood type and univariate and multivariate analysis correlation.Overall,the patient’s blood type A deterioration in terms of recurrence and progression rate than those who are O-type(P = 0.0469,P = 0.0175),B-type blood(P = 0.003,P = 0.0004)and AB blood type(P = 0.0146,P = 0.0002)in patients with a higher incidence.Conclusion: The primary non-muscle invasive bladder cancer patients,ABO blood type can affect the prognosis,in A,B,O,AB blood type A blood type of patients has the highest rate of tumor recurrence and progression of disease.Deletion allele may be one of the mechanisms of bladder cancer recurrence and progression.Due to the widespread popularity of the ABO blood group,it can be forecast with primary non-muscle invasive bladder cancer recurrence and progression of an ideal auxiliary markers.