The Clinical Studies Of Acupuncture Treatment On The Effects Of Gut Microbiota Of Patients With Simple Obesity

Objective: To observe the efficacy of the acupuncture treatment to patients with simple obesity,especially to pay attention to the changes of gut microbiota.To discuss the relationship between gut microbiota and obesity.Supporting the “invigorating spleen and warming the kidney” as the method for treatment of simple obesity,providing objective theoretical basis for clinical prevention and treatment.Methods: 60 cases with simple obesity who were in accord with diagnostic criteria were randomly divided into two groups,each group had 30 patients.They were 30 cases in the treatment group,30 cases in the control group.All patients of the control group were educated the knowledge of health,diet control and reasonable exercise.Besides,the treatment group was treated by acupuncture.Two groups were given their corresponding treatments once every other day,10 days were a treatment course.After three periods,the effect was observed.And choose 30 cases in the health groups.Detecting the changes of the two groups and health groups main bacteria in the intestine by using QRT-PCR,also the height,body weight,body mass index,waist circumference,hip circumference,waist/hip ratio symptom integral,traditional Chinese medicine clinical therapeutic effect,blood fat in two groups were observed before and after the treatment.The complete data carries on statistics analysis by the SPSS17.0 statistics software.Results:(1)Intestinal flora: Before treatment,the amount of enterobac teria and enterococcus in treatment group and control group were higher then healthy group.after treatment,the amount of enterobacteria and enterococcus in treatment group had statistical significance between pre and post treatment(P <0.05),compared with the health groups had no statistical significance(P>0.05).The control group had no statistical signific ance between pre and post treatment(P>0.05),compared with the healthy group had statistical significance(P<0.05).Before treatment,the amount of bacteroides in treatment group and control group were less then healthy group.After treatment,the amount of bacteroides in treatment group had statistical significance between pre and post treatment(P<0.05),compared with the health groups had no statistical significance(P>0.05).The control group had no statistical significance between pre and post treatment(P >0.05),compared with the healthy group had statistical significance(P <0.05).The amount of bifidobacterium and lactobacillus in treatment group and control group had no statistical significance compared with the healthy group between pre and post treatment(P>0.05).(2)Weight,BMI,WHR: after treatment,the weight,BMI,WHR in treatment group had statistical significance between pre and post treatment(P <0.05),and the control group had no statistical significance between pre and post treatment(P >0.05).(3)Blood fat: after treatment,the treatment group had statistical significance in all aspects between pre and post treat ment(P <0.05),and control group had statistical significance between pre and post treatment(P <0.05)except HDL-C.(4)The main symptoms inte gral of TCM: after treatment,the symptom scores of treatment group was significantly increased,compared with the control group had statistical significance(P﹤0.05).(5)Clinical therapeutic effect evaluation of TCM : after treatment,The curative indexs of symptoms integral of two groups were scored.In all patients of treatment group,7cases were significantly effective,20 cases were effective,3 cases were ineffective and the total effective rate was 90.0%.In those of control group 1case was significantly effective,9cases were effective,20 cases were ineffective and the total effective rate was 30.3%.The clinical efficacy of treatment group is better than control group.Conclusion:(1)Intestinal flora is closely related to the occurrence of obesity,may be human intestinal flora disturbance is one of the important mechanism of simple obesity.(2)The acupuncture and moxibustion in treating obesity may be through the mechanism of adjusting the intestinal flora,restore dynamic balance of the body’s micro ecology,correct the abnormal metabolism,promote energy cost,achieve the effect of losing weight.(3)The“invigorating spleen and warming the kidney” as the principle has clinical significance in the treatment of sample obesity and based on this creation of the acupuncture prescription is reasonable and effective.