Correlation Between The Level Of Inhibition C,Glycated Hemoglobin A1c And The Coronary Lesions

Background and purpose: Coronary atherosclerotic heart disease(Coronary atherosclerotic heart diseases, CHD), called coronary heart disease for short, which is the most common type of atherosclerotic disease, and is also one of the important diseases endangering human health. In the last century, coronary heart disease in Europe and the United States, ranked first in the causes of death. In recent years, with the change of social environment and life style, coronary heart disease has gradually become one of the main diseases that aggrieves people, s health in our country. At present, there are a great number of studies on the risk factors of coronary heart disease in medicine. The famous Framingham heart study, a long-term study of cardiovascular diseases, has made a great contribution to the study of cardiovascular diseases and the analysis of risk factors. The risk factors of Coronary heart disease contain: age, gender, dyslipidemia(increased high cholesterol, triglyceride, high density lipoprotein cholesterol is too low), hypertension, smoking, diabetes, sugar intolerance and so on. Other risk factors include obesity, positive family history,personality, and lack of physical exercise, etc.. In recent years, some emerging risk factors include: high homocysteine, insulin resistance, lipoprotein(alpha), blood coagulation factors, as well as fibrinogen, chlamydia, viral infections, etc.. The study on the risk factors of cardiovascular diseass has become a part of modern medicine. Diabetes is equally dangerous to the coronary heart disease [1]. In recent years, the American Diabetes Association(ADA) has used the glycosylated hemoglobin(Hb A1c) as one of the diagnostic indicators of diabetes [2]. Many studies have been found that Hb A1 c is closely related to the occurrence and development of atherosclerotic stenosis. Cystatin C(Cys C),regarded as a cysteine protease inhibitor, which mainly through regulating cell protease activity, avoids inappropriate endogenous or exogenous proteases from damaging the body cells, and plays a role in cell protection. Cystatin C is one of the most important indicator of renal dysfunction. In recent years, many domestic and foreign researches have found that Cys-C is closely related to the occurrence and development of cardiovascular diseases, and reflects the effect of non renal function. This paper mainly studied the relationship between cystatin C, Hb A1 c and coronary artery lesions, further understanding of the clinical significance about them, prowiding a new way to prevent and control cardiovascular diseases.Materials and methods: Methods: Choose 216 Patients diagnosed coronary heart disease that recruited from the Second Affiliated Hospital of Zhengzhou University from Jan. 2014 to Mar. 2015 as the research object, their ages range from 38 years old to 83 years old. According to the results of coronary angiography, all the selected patients were divided into 113 cases of CHD group(68 males and 45 females), 71 cases of normal coronary angiography as control group(43 males and 28 females).According to the results of coronary lesions counts,patients with coronary heart disease were divided into three groups: single vessel lesion group(22 cases), double vessel lesion group(42 cases), multiple vessel disease group(49 cases). The severity of coronary artery lesions were divided into three groups according to the Gensini score, mild: Gensini score < 20 points(65 cases), moderate: 20 points is less than or equal to Gensini score < 40 points(21 cases), severe: Gensini score greater than or equal to 40 points(27 cases). The general information and related indexes of all the selected persons were collected. Detect Hb A1 c and Cys-C by immune turbidimetry. The data were analyzed by SPSS17.0 software. Observe the relationship between cystatin C,Hb A1 c and coronary artery disease.Results: 1. Compared the CHD group with control group of the general information about age, history of hypertension, history of diabetes, smoking, body mass index, creatinine, fasting blood glucose and blood lipids and so on, the differences are not statistically significant(P > 0.05); The levels of Hb A1 c and cystatin C of Coronary heart disease group e significantly higher than that of control group, and the differences are statistically significant(P < 0.05). 2. With the number of lesions counts and the Gensini score increasing, the level of Hb A1 c and cystatin C also gradually increase, the differences are statistically significant(P < 0.05). 3. Hb A1 c and cystatin C were positively correlated with the number of diseased coronary arteries and Gensini scores(P < 0.05). 4. Logistic regression analysis showed that cystatin C(t =, P = 0.035), Hb A1c(t=5.41, P < 0.001) were risk factors to coronary artery disease.Conclusion: 1. The positive correlation between Cy s- C, Hb A1 c and coronary artery lesions counts,the severity of coronary artery lesions. 2. Cy s- C, Hb A1 c are risk factors for coronary heart disease(CHD), which can predict the severity of coronary artery lesion.