| Objectives: To investigate the efficacy and safety of acupuncture for migraine prophylaxis by systematic reviews and Meta-analysis; To investigate selection of points of acupuncture for migraine prophylaxis base on data mining technology.Methods: To formulate inclusion criteria, exclusion criteria and search methods base on Cochrane Handbook for Systematic Reviews of Interventions5.1.0;Two reviewers extracted information on patients, interventions, methods and results with data collection forms which designed by Cochrane Handbook for Systematic Reviews of Interventions5.1.0 and the characteristic of acupuncture independently; assessed risk of bias and quality of the acupuncture intervention; To investigate efficacy and safety of acupuncture for migraine prophylaxis by Revman5.3.Used Response, migraine days, migraine frequency, migraine intensity, analgesic use, migraine duration time, PDI, MIDAS, SF-36 or SF-12 as the outcome to evaluate the efficacy. Utilized the number of side effects to evaluate the safety. Count data calculate the relative risk(Relative Risk, RR) and 95% confidence interval(confidence interval, CI) and measurement data calculate standardized mean difference(standardized mean difference, SMD) and 95% confidence interval. Established form of selection of points of acupuncture for migraine prophylaxis with Access2013 and analyzed the data with SPSS Modeler14.1.Result:1.Twenty-six trials with 3657 participants met the inclusion criteria. Fifteen trials reported in english and eleven trials reported in chinese.2.To make subgroups with time points compared with the blank control a total of 18 indexes, compared with sham acupuncture in a total of 38 indexes, compared with western medicine, a total of 34 indexes.3.Result of Meta-analysis: compared with the blank control, acupuncture is more effective for migraine prophylaxis in 14 indexes and 4 indexes showed no significant statistical difference; Compared with sham acupuncture, 7 indexes showed acupuncture is more effective for migraine prophylaxis than sham acupuncture, sham acupuncture is more effective in 2 indexes, the other 29 indicators showed no significant statistical difference; Compared with drug, 22 indexes are more effective,12 indexes showed no significant statistical difference.4.The top three points of acupuncture for migraine prophylaxis are fengchi, shaigu, taiyang; It produced 82 association rules and those rules are important:shuaigu?feng chi, taiyang?fengchi, taichong?fengchi, taiyang+shuaigu?fengchi, sanyinjiao+fengchi?taiyang, sanyinjiao+taiyang?shuaigu, sanyinjiao+taiyang+shuaigu?fengchi, taichong+ shuaigu+fengchi?taiyang.Conclusion: Evidence support of acupuncture for migraine prophylaxis was considered promising,acupuncture is as efficient as western medicine for migraine prophylaxis at least and more safe. There is no evidence for an effect of true acupuncture over sham acupuncture. Fengci, shuaigu, taiyang may be the most useful point for migraine prophylaxis and they often be combined with sanyinjiao, taichong. |
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