The Research Of The Relationship Between Blood Lipid,Uric Acid And Carotid Atherosclerosis Of The Yao Nationality In Jianghua

Objective: The main purpose of the study is that by researching the relationship between blood lipid, uric acid and carotid atherosclerosis of the Yao nationality in Jianghua. By which can provide an objective basis for forecasting the appearance and development of cardiovascular and cerebrovascular diseases of Yao population in Jianghua and taking for the intervention measures to reduce the progress of atherosclerosis and prevent the occurrence of cardiovascular and cerebrovascular diseases.Method: 1.Object and Method:300 patients of Yao nationality for physical examination or hospitalization were recruited in Jianghua People’s Hospital from January 2015 to December 2015 hospital. All patients had underwent carotid artery ultrasound. Exclusion criteria:(1)hypertension;(2)diabetes;(3)severe liver and kidney dysfunction;(4) malignant tumor;(5) serious cardiovascular and cerebrovascular diseases;(6)the long-term use of reducing blood lipid and uric acid lowering drugs. 2. According to the patients with carotid artery IMT(0.9mm < carotid artery IMT < 1.3mm) 、(carotid artery IMT ≥1.3 mm) 、(carotid artery IMT< 0.9mm) divided into thickening group(92 cases),plaque group(108 cases), control group(100 cases). General informations(age, gender, smoking), fasting blood glucose(FBG), serum creatinine, triglyeride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), homocysteine, blood uric acid(UA), were compared with 100 cases normal control group. According to whether hyperuricemia, 300 patients were divided into high uric acid group and normal uric acid group, comparing the difference between the two groups of TC, TG, HDL-C, LDL-C levels, and the correlation between the level of uric acid and blood lipid. 3. Statistical analysis: using SPSS 18.0 statistical software, count data using chi square test, comparison between the two groups were analyzed by T test, variance analysis was used in the comparison between groups. Multivariate logistic regression analysis after single factor analysis. Correlation analysis using Pearson correlation analysis, P<0.05 was statistically significant.Results: 1. Patients of Yao nationality for physical examination or hospitalization were recruited in Jianghua People’s Hospital from January 2015 to December 2015 hospital.All patients had underwent carotid artery ultrasound, including 300 patients, age range 52-80 years, average age 62.85 + 0.45 years old, including 148 males(49.3%),152 females(50.7%). Normal control group 51 males(51%),49 females(49%), smoking 29 cases(29%), non-smoking 71 cases(71%); thickening group 44 males(47.8%), 48 females(52.2%),smoking 26 cases(28.3%), non-smoking 66 cases(71.7%); plaque group 53 males(49.1%), 55 females(50.9%), smoking 25 cases(23.1%), non-smoking 83 cases(76.9%). 2. Single factor analysis: TC, LDL-C, HDL-C,UA had statistical significance(P<0.05).3.Multivariate analysis: TC, LDL-C, HDL-C,OR(95%CI) were: 4.931(2.389,4.487),2.355(1.024,5.418),2.607(1.170,5.807),P<0.05,UA,OR(95%CI)were:1.490(0.714,3.108),P>0.05. 4. The simple correlation analysis between UA and serum lipids: TC and UA(r=0.401,P<0.05)were positively correlated;LDL-C and UA( r=0.306, P<0.05) were positively correlated; HDL-C and UA(r=-0.191,P<0.05)were negatively correlated.Conclusion: 1. LDL-C and TC were relational risk factors for carotid atherosclerosis of Yao nationality in Jianghua, HDL-C was relational protect factors for carotid atherosclerosis of Yao nationality in Jianghua. 2.UA was positively correlated with TC and LDL-C, and negatively correlated with HDL-C, suggesting that the UA may promote the formation of carotid atherosclerosis by blood lipid.