Effects Of Arsenic Trioxide On Apoptosis And Proliferation Of Human Lung Cancer Cells Under The Condition Of The Change Of Oxygen

Objective:To evaluate the clinical effects of maintenance therapy combining of autologous dentritic cells( DC) and cytokine induced killer cells( CIK cells) and gefitinib on patients with advanced non-small cell lung cancer( NSCLC).Methods:100 patients(62-87 years old) with Stage-?b and ? NSCLC underwent 4 cycles of platinum-based two-drug chemotherapy and achieved stable status or much better condition. The patients were randomized into 2 groups, i.e., combination therapy group,which received a biological immunotherapy combining gefitinib and autologous DC/CIK cells, and gefitinib therapy group, which was given gefitinib therapy alone. Efficacy, the TGF-? of serum and the level of immune cells were evaluated.Results:Serum TGF-beta 1: two groups after treatment than before treatment serum levels of TGF-beta 1 descent(P<0.05), the treatment group than the control group significantly(P<0.05). Peripheral blood lymphocyte phenotype: after treatment, the treatment group peripheral blood CD3+?CD 4+?CD 8+and CD4+/ CD 8+has obvious difference to the control group compared, compare two groups was statistically significant(P<0.05).Adverse reactions: the treatment group received DC and CIK cells infusion fever 7 cases,after appropriate treatment. The rash and diarrhea incidence is similar between the two groups was statistically significant(P<0.05).Conclusions:The maintenance treatment combining gefitinib and autologous DC/CIK cells maybe can down-regulate the level of TGF-? in the serum and improve immunity of patients with advanced NSCLC.