Expression Of Src In Breast Cancer And Its Relationship With Prognosis

Breast cancer is one of the most commonly diagnosed female cancers, and the 5-year prevalence of breast cancer is the highest among all kinds of cancers in women in China. The comprehensive treatment of breast cancer includes surgery, chemotherapy, radiotherapy, antiestrogen therapy, targeted therapy and so on. Although these therapies have been extremely effective in treating breast cancer, there are still some patients with poor treatment effect, or even lack of effective treatment. Therefore, identifying new therapy targets in breast cancer is a high clinical priority. Src is regulatory protein, playing a key role not only in cell differentiation, motility, invasion, proliferation and cell survival, but also in the advancement and metastasis of solid tumors. This study aimed to explore Src expression and to evaluate its effects on the prognosis of breast cancer. We used immunohistochemistry technique to measure Src expression in 262 invasive breast cancer patients via tissue microarrays. Clinical data were analyzed in retrospect. Survival analysis and the Cox proportional hazards model were used to explore the prognostic value of Src expression in breast cancer. The Src expression rate in 262 breast cancer patients was 47.3%. Src expression was significantly associated with lymph node metastasis and HER2 expression(P=0.021, P=0.005, respectively). Patients who exhibited Src expression demonstrated poor overall survival(P=0.022). Subgroup analysis demonstrated that lymph node metastasis negative/ Src high expression patients and Luminal A/ Src high expression patients exhibited significantly worse overall survival(P=0.009,P=0.022,respectively). Multivariate analysis demonstrated that Src expression was an independent predictor of poor prognosis in breast cancer patients. Therefore, Src high expression predicts a poor prognosis in breast cancer patients. For lymph node metastasis negative/ Src high expression patients and Luminal A/ Src high expression patients, Src high expression is closely related to the poor prognosis, and Src target therapy may improve the treatment effect of such patients.