Study On Superparamagnetic Iron Oxide Nanoparticles As MRI Contrast Agent In Early Diagnosis Of Liver Cancer And Its Pilot Production

The magnetic resonance imaging(MRI) techniques can achieve multiple perspectives and multiplanar imaging of human body with high resolution. MRI can differentiate the anatomical tissue and adjacent fatty tissue in human body objectively in details, and locate to lesions accurately. These characteristics of MRI have great practical significance for the diagnosis, especially early stage tumor.Superparamagnetic iron oxide particles(SPIO) as a new type of MRI imaging contrast agent with superparamagnetism, small size, high relaxation rate, high biocompatibility and other characteristics. Compare with gadolinium(Gd) paramagnetic contrast agent, its imaging performance is better. Because of the MRI contrast agent in clinical use, SPIO will have broad prospect of medical applications.The goal of this study is to establish a MRI contrast agent which could have the potential to be used in clinic. The synthesis method has been scaled up to multiple gram level as a pilot product in order to satisfy the need in the clinical applications.The main results are:1) Small-scale synthesis shows that the method is feasible and get good quality product.2) In the pilot production, with good control of the procedure we confirmed the best technological parameter.3) Pilot product show good performance as a contrast agent in the MR imaging in subcutaneous tumor model and cirrhosis model...