Study On The T Cell Immunity,Psychology And Family Environment Of Children With Tic Disorders (TD)

Object:1.To investigate the level of T lymphocyte subsets in TD children’s blood in order to detect the role of T cell immunity in tic disorder children and pathogenesis status.2.Through relevant questionnaires to observe and analyze the effects of psychological and family environment on children with tic disorders.3.To summarize the relationship among TD and cell immunity,psychology and family environment.Methods:The experimental group of TD children(66 cases)and the control group of normal children(60 cases)were collected to determine the level of different T lymphocyte subsets.All children completed the following scales:the Family Cohesion and Adaptability Scale(FACES),the Family Environment Scale-Chinese Version(FES-CV),the Eysenck Personality Questionnaire(EPQ),the Yale Globle Tic Severity Scale(YGTSS)and other children mental health scales.Statistical analyses were performed by the chi-square test,analysis of variance and Binary logistic regression with SPSS/PC package.Results:1.Two groups of children of different functions of T lymphocytes test results showed that:the level of CD3,CD4and CD4/CD8 in TD children group were lower than the control group of normal children,the test data results significant difference(P<0.05);and the level of CD8 in TD group higher than normal children,but after testing this difference P>0.05,so the difference was not statistically significant.2.The proportion of T lymphocyte subsets in children with tic disorders of different Clinical classifications:CD3,CD4 and CD4/CD8 in the TS group were the lowest among the three Clinical classifications,The difference was statistically significant(P<0.05).3.Mild and moderate to severe tic group set different functions of T lymphocytes test results showed:mild tic group CD3,CD4 and CD4/CD8 were higher than those with moderate to severe tics group(P<0.05,P<0.01 P<0.01);Mild tic group CD8 was lower than moderate and severe groups.The above indexes in comorbidity and no comorbidity,such asADHD,in children with tic disorders are different,but no statistical significance,P>0.05.4.Results of FES-CV:there was no significant difference between the three functions of family independence,success and control in the experimental group of TD children,P>0.05.The scores of the other seven functions of family were lower in the experimental group than in the normal group.The difference was statistically significant(P<0.01).5.Results of FACE Ⅱ:The scores of the experimental group were lower than that of the normal children in terms of actual cohesion,actual adaptability and ideal adaptability,The difference was statistically significant(P<0.01、P<0.01、P<0.01).The stiff and loose family patterns in the experimental group were higher than those of the normal control group(P<0.05、P<0.05).Flexible family pattern was less than normal control group(P<0.05).6.The datas were analyzed by Logistic regression analysis:CD3、CD4、CD8 andCD4/CD8 in T cell immunity are risk factors of TD.Through multiple linear regression analysis,we found that the attitude of parents,the total score of anxiety,the level of mother’s education and the degree of cohesion were the risk factors of tic disorders.Conclusion:1.CD3、CD4、CD8 andCD4/CD8 are risk factors of TD,and the more severe disease the more confused cellular immune function.2.Family Environment and patterns are associated with TD.In the treatment of children with TD at the same time,we need to interfere with poor family Environment and education.3.Children with TD are more prone to depression,anxiety and other negative emotions,and have poor self-control ability and adaptability.So Psychological counseling is very important for children with tic disorders.