The Clinical Survey And Susceptible Genes Screening Of Recurrent Acute Pancreatitis

Part one The clinical features of recurrent acute pancreatitisObjective: The Morbidity of recurrent acute pancreatitis is high.The main clinical manifestation of recurrent acute pancreatitis is repeat attack of acute pancreatitis,which bring great pain to patients,but also bring great medical burden.The purpose of our study was to analyze the clinical features of recurrent acute pancreatitis,and to compare with features of chronic pancreatitis.Methods:Between January 2016 to July 2016,we collected and follow-up the clinical data of patients who diagnosed as recurrent acute pancreatitis or chronic pancreatitis in Changhai Hospital of Shanghai.A prospective cohort study was set to compare the difference of clinical features between the two contacts.Results: 1.The male’s morbidity is 69 %(RAP group)and 60.4 %(CP group).2.The average first onset age of RAP and CP is 38.27 and 20.72 respectivly;teenagers accounted for 12%vs38.6%.3.The incidence of diabetes was 49.5%vs9%;the incidence of fatty diarrhea was 46.6%vs19% of the two groups.4.The cumulative incidence of CP was 2% within 1 year,4.6% in 3 years,and 12.4% in 5 years.Conclusion:1.Male has higher morbidity in both RAP group(n=100)and CP group(n=101).2.CP’s first onset was younger than RAP.Teenagers have a higher incidence in CP group.3.The risk of diabetes and fatty diarrhea is much higher in CP group than RAP group.4.Part of the RAP will progress to CP.Part two The screening of susceptibility genes of idiopathic recurrent acutepancreatitisObjective: This study based on susceptibility genes screening of enrolled patients and establish the database of genetic characteristics of Chinese patients.To explore the pathogenic potential sites and provide a theoretical basis and new ideas for the further study.Methods:A prospective study with IRAP patients who were admitted to changhai hospital from Jan 2016 to Jan 2017 was conducted.We collected clinical data and blood sample of IRAP patients according to inclusion / exclusion criteria.All samples were subjected to high throughput sequencing,involving 27 genes.Then we analyzed the results by compare to genetic database.Results:21gene with 128 sites were detected.By comparing with 1000 G database,8 susceptibility genes were found: SPINK1,CTSB,PCSK9,CASR,FUT2,ANK3,GGT1,and SEC16 A.By comparing with Ex AC database,8 susceptibility genes were found: SPINK1,CFTR,CTSB,PCSK9,FUT2,ANK3,GGT1,and SEC16 A.Conclusion:1、The distribution of IRAP gene mutation has a certain concentration trend,and potential susceptible genes can be find.2、More research is needed to verify the function of these genes.